C1QA and UBQLN2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		C1QA	UBQLN2
Gene Name		complement component 1, q subcomponent, A chain	ubiquilin 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Innate Immune Response
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG PIAS2 PPP1CA PPP1CC PTX3 SGTA SLC25A47 UBQLN1 UBQLN2	17 interactors: ADRM1 ATXN7 BTRC C1QA CD93 FAF2 FBXO25 HERC3 HERPUD1 HSPA13 PRPF40A PSMA2 PSMD4 RNF11 RPN1 UBE3A UBQLN4
Entrez ID		712	29978
HPRD ID		00393	02224
Ensembl ID		ENSG00000173372	ENSG00000188021
Uniprot IDs		P02745	B4DZF1 Q9UHD9
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV	1J8C
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Defense Response Protein Metabolic Process Positive Regulation Of Immune Response Immune System Process Innate Immune Response Response To Stress Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Acute-phase Response Response To Stimulus Regulation Of Protein Metabolic Process Dermatan Sulfate Biosynthetic Process Opsonization Regulation Of Acute Inflammatory Response Acute Inflammatory Response Negative Regulation Of Signal Transduction Negative Regulation Of Glycoprotein Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Negative Regulation Of Signaling Extracellular Matrix Disassembly Negative Regulation Of Viral Entry Into Host Cell Proteoglycan Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Triglyceride Catabolic Process Chondroitin Sulfate Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Wound Healing Chondroitin Sulfate Proteoglycan Biosynthetic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process See more	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Polyubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Viral Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Cellular Protein Modification Process Catabolic Process Positive Regulation Of Protein Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Autoubiquitination Positive Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Sperm Entry Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint See more
Tagcloud ?		abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant	als2 c147r causative chmp2b dao dctn1 diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp vapb vcp
Tagcloud (Difference) ?		abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant	als2 c147r causative chmp2b dao dctn1 diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp vapb vcp
Tagcloud (Intersection) ?