C1QA and CR1

Number of citations: 0 (PubMedID 10528211)
Data Source: HPRD (in vitro)

		C1QA	CR1
Name		complement C1q A chain	complement C3b/C4b receptor 1 (Knops blood group)
Structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface	Extracellular Space Cytoskeleton Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Plasma Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Amyloid-beta Binding Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding	Virus Receptor Activity Complement Binding Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Receptor Activity Complement Component C3b Receptor Activity Protein Binding
	Biological Process	Microglial Cell Activation Immune System Process Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Neuron Remodeling Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning	Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Complement Receptor Mediated Signaling Pathway Immune Complex Clearance By Erythrocytes T Cell Mediated Immunity Negative Regulation Of Immunoglobulin Production Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Plasma Membrane Organization Positive Regulation Of Cell Population Proliferation Regulation Of Complement Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Plasma Cell Differentiation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity ATP Export
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade
Drugs		Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab	None
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	None
GWAS		Inflammatory biomarkers (multivariate analysis) ( 33110245 )	Alzheimer's disease ( 21460840 31473137 19734903 ) Alzheimer's disease (late onset) ( 28714976 30617256 24162737 21460841 ) Alzheimer's disease (onset between ages 58 and 79) ( 30979435 ) Alzheimer's disease in APOE e4+ carriers ( 25778476 ) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717 ) Erythrocyte sedimentation rate ( 21700265 ) Family history of Alzheimer's disease ( 30617256 ) Inflammatory biomarkers ( 22291609 ) Metabolite levels ( 23823483 ) Refractive error ( 32231278 ) Systemic sclerosis ( 29293537 )
Novel Interactors		1 novel interactors: RHOA	None recorded
Interacting Genes		31 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HMGB1 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 SGTA SGTB SLC25A47 TXN UBQLN1 UBQLN2 USP40	6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4
Entrez ID		712	1378
HPRD ID		00393	00398
Ensembl ID		ENSG00000173372	ENSG00000203710
Uniprot IDs		P02745	E9PDY4 P17927
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U	1GKG 1GKN 1PPQ 2MCY 2MCZ 2Q7Z 5FO9
GO Terms Enriched among Interactors		Complement Component C1q Complex Binding Complement Activation, Classical Pathway Complement Component C1 Complex Complement Activation Blood Microparticle Cell Surface Opsonization Immune Effector Process Positive Regulation Of ERAD Pathway Symbiont Cell Surface Defense Response To Symbiont Defense Response To Other Organism Regulation Of ERAD Pathway Innate Immune Response Regulation Of Protein Metabolic Process Extracellular Region Response To Stress Humoral Immune Response Virion Binding Activation Of Immune Response Extracellular Matrix Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To External Biotic Stimulus Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Defense Response Response To Other Organism Negative Regulation By Host Of Viral Glycoprotein Metabolic Process TRC Complex Regulation Of Immune Response Immune Response Extracellular Space Identical Protein Binding Negative Regulation Of Endothelial Cell Migration Complement Component C1q Complex Positive Regulation Of Immune System Process Protein Targeting To ER Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Multicellular Organismal Development Establishment Of Protein Localization To Endoplasmic Reticulum IgM Binding Positive Regulation Of Proteolysis Negative Regulation Of Immune System Process Polyubiquitin Modification-dependent Protein Binding Acute-phase Response Positive Regulation Of Proteasomal Protein Catabolic Process Postsynapse	Complement Activation, Classical Pathway Complement Activation Humoral Immune Response Symbiont Cell Surface Positive Regulation Of Immune System Process Immune Effector Process Regulation Of Complement Activation Activation Of Immune Response Defense Response Vertebrate Eye-specific Patterning Classical-complement-pathway C3/C5 Convertase Complex Cell Surface Innate Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Complement-mediated Synapse Pruning Regulation Of Immune System Process Defense Response To Symbiont Defense Response To Other Organism Immune System Process Complement Binding Positive Regulation Of Apoptotic Cell Clearance Regulation Of Immune Response Synapse Pruning Regulation Of Apoptotic Cell Clearance Response To Other Organism Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Neuron Remodeling Immune Response Complement Receptor Mediated Signaling Pathway Negative Regulation Of Complement Activation Complement Activation, Alternative Pathway Opsonization Response To External Biotic Stimulus Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Stress Regulation Of Adaptive Immune Response Neuron Maturation Antigen Binding Endopeptidase Inhibitor Activity Positive Regulation Of Phagocytosis Virus Receptor Activity C5L2 Anaphylatoxin Chemotactic Receptor Binding Regulation Of Phagocytosis Inflammatory Response Leukocyte Activation Positive Regulation Of Activation Of Membrane Attack Complex