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C1QA and SLC25A47
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
C1QA
SLC25A47
Description
complement C1q A chain
solute carrier family 25 member 47
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Complement Component C1 Complex
Cell Surface
Extracellular Matrix
Synapse
Complement Component C1q Complex
Postsynapse
Extrinsic Component Of Presynaptic Membrane
Extrinsic Component Of Postsynaptic Membrane
Glutamatergic Synapse
Symbiont Cell Surface
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Membrane
Molecular Function
Amyloid-beta Binding
Phosphatidylserine Binding
IgM Binding
Protein Binding
IgG Binding
Acetyl-CoA Transmembrane Transporter Activity
Transmembrane Transporter Activity
NAD Transmembrane Transporter Activity
Biological Process
Microglial Cell Activation
Immune System Process
Complement Activation
Complement Activation, Classical Pathway
Cell-cell Signaling
Neuron Remodeling
Innate Immune Response
Astrocyte Activation
Synapse Organization
Synapse Pruning
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Acetyl-CoA Transport
NAD Transmembrane Transport
Transmembrane Transport
Pathways
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade
Drugs
Cetuximab
Etanercept
Palivizumab
Daclizumab
Bevacizumab
Diseases
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Apolipoprotein A1 levels (
32203549
)
Glycated hemoglobin levels (
34059833
)
Interacting Genes
31 interacting genes:
APCS
BAG6
C1QB
C1QBP
C1QC
C1R
C1S
CD93
COL2A1
CR1
CRP
CSPG4
DCN
FN1
GNPNAT1
HIPK3
HMGB1
HRG
HSPB2
NLGN3
PIAS2
PPP1CA
PPP1CC
PTX3
SGTA
SGTB
SLC25A47
TXN
UBQLN1
UBQLN2
USP40
2 interacting genes:
C1QA
DIABLO
Entrez ID
712
283600
HPRD ID
00393
16620
Ensembl ID
ENSG00000173372
ENSG00000140107
Uniprot IDs
P02745
G3V374
Q6Q0C1
PDB IDs
1PK6
2JG8
2JG9
2WNU
2WNV
5HKJ
5HZF
6FCZ
6Z6V
9C9L
9C9U
Enriched GO Terms of Interacting Partners
?
Complement Component C1q Complex Binding
Complement Activation, Classical Pathway
Complement Component C1 Complex
Complement Activation
Blood Microparticle
Cell Surface
Opsonization
Immune Effector Process
Positive Regulation Of ERAD Pathway
Symbiont Cell Surface
Defense Response To Symbiont
Defense Response To Other Organism
Regulation Of ERAD Pathway
Innate Immune Response
Regulation Of Protein Metabolic Process
Extracellular Region
Response To Stress
Humoral Immune Response
Virion Binding
Activation Of Immune Response
Extracellular Matrix
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Response To External Biotic Stimulus
Regulation Of Immune System Process
Immune System Process
Positive Regulation Of Immune Response
Defense Response
Response To Other Organism
Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
TRC Complex
Regulation Of Immune Response
Immune Response
Extracellular Space
Identical Protein Binding
Negative Regulation Of Endothelial Cell Migration
Complement Component C1q Complex
Positive Regulation Of Immune System Process
Protein Targeting To ER
Regulation Of Response To Endoplasmic Reticulum Stress
ERAD Pathway
Regulation Of Multicellular Organismal Development
Establishment Of Protein Localization To Endoplasmic Reticulum
IgM Binding
Positive Regulation Of Proteolysis
Negative Regulation Of Immune System Process
Polyubiquitin Modification-dependent Protein Binding
Acute-phase Response
Positive Regulation Of Proteasomal Protein Catabolic Process
Postsynapse
Complement Component C1q Complex
IgM Binding
Complement Component C1 Complex
Vertebrate Eye-specific Patterning
Extrinsic Component Of Presynaptic Membrane
Complement-mediated Synapse Pruning
Extrinsic Component Of Postsynaptic Membrane
Neuron Remodeling
IgG Binding
Synapse Pruning
CD40 Receptor Complex
Symbiont Cell Surface
Astrocyte Activation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Neuron Maturation
Microglial Cell Activation
Leukocyte Activation Involved In Inflammatory Response
Complement Activation, Classical Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Complement Activation
Phosphatidylserine Binding
Macrophage Activation
Collagen Trimer
Mitochondrial Intermembrane Space
Amyloid-beta Binding
Neuron Apoptotic Process
Cytoplasmic Side Of Plasma Membrane
Extrinsic Apoptotic Signaling Pathway
Myeloid Leukocyte Activation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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