C1QA and PTX3

Number of citations of the paper that reports this interaction (PMID 12645945)
35

Data Source:
HPRD (in vitro, in vivo)

		C1QA	PTX3
Gene Name		complement component 1, q subcomponent, A chain	pentraxin 3, long
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding	Complement Component C1q Binding (1->3)-beta-D-glucan Binding Virion Binding
	Biological Process	Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Innate Immune Response	Response To Yeast Inflammatory Response Opsonization Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG PIAS2 PPP1CA PPP1CC PTX3 SGTA SLC25A47 UBQLN1 UBQLN2	5 interactors: C1QA C1QB C1QC CFH FGF2
Entrez ID		712	5806
HPRD ID		00393	03928
Ensembl ID		ENSG00000173372	ENSG00000163661
Uniprot IDs		P02745	P26022
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Defense Response Protein Metabolic Process Positive Regulation Of Immune Response Immune System Process Innate Immune Response Response To Stress Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Acute-phase Response Response To Stimulus Regulation Of Protein Metabolic Process Dermatan Sulfate Biosynthetic Process Opsonization Regulation Of Acute Inflammatory Response Acute Inflammatory Response Negative Regulation Of Signal Transduction Negative Regulation Of Glycoprotein Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Negative Regulation Of Signaling Extracellular Matrix Disassembly Negative Regulation Of Viral Entry Into Host Cell Proteoglycan Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Triglyceride Catabolic Process Chondroitin Sulfate Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Wound Healing Chondroitin Sulfate Proteoglycan Biosynthetic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process	Complement Activation Protein Activation Cascade Humoral Immune Response Innate Immune Response Regulation Of Immune Response Immune Response Regulation Of Immune System Process Defense Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Immune Response Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Immune System Process Positive Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Response To Stress Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Fate Specification Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Chondroblast Differentiation Inositol Phosphate Biosynthetic Process Regulation Of Satellite Cell Proliferation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Macrophage Differentiation Complement Activation, Alternative Pathway Negative Regulation Of Fibroblast Migration Hyaluronan Catabolic Process Positive Regulation Of Cell Fate Commitment Regulation Of Sprouting Angiogenesis Regulation Of Cell Fate Specification Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Migration Involved In Sprouting Angiogenesis Response To Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Chemotaxis Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Fibroblast Migration Blood Vessel Endothelial Cell Migration Regulation Of Complement Activation Regulation Of Cell Fate Commitment Negative Regulation Of Endothelial Cell Migration Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Heart Growth
Tagcloud ?		abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant	0288mg 072pg 161mg 161pg 1beta accumulating beta1 contributes crp daily diverse divided ds enrolled epilepsy frequent generalized hs inflammatory intermittent intractable motor organs pathomechanism pathophysiology pentraxin presenting seizures treat
Tagcloud (Difference) ?		abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant	0288mg 072pg 161mg 161pg 1beta accumulating beta1 contributes crp daily diverse divided ds enrolled epilepsy frequent generalized hs inflammatory intermittent intractable motor organs pathomechanism pathophysiology pentraxin presenting seizures treat
Tagcloud (Intersection) ?