C1QA and C1QC

Number of citations: 0 (PubMedID 12960167)
Data Source: HPRD (in vitro)

		C1QA	C1QC
Name		complement C1q A chain	complement C1q C chain
Structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Space Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Blood Microparticle Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface
	Molecular Function	Amyloid-beta Binding Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding	Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding
	Biological Process	Microglial Cell Activation Immune System Process Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Neuron Remodeling Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning	Immune System Process Immune Response Complement Activation, Classical Pathway Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation Synapse Pruning
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab	Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Inflammatory biomarkers (multivariate analysis) ( 33110245 )	Blood protein levels ( 30072576 )
Interacting Genes		31 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HMGB1 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 SGTA SGTB SLC25A47 TXN UBQLN1 UBQLN2 USP40	6 interacting genes: C1QA C1QB FKBP2 PTX3 UBQLN2 ZNF534
Entrez ID		712	714
HPRD ID		00393	00395
Ensembl ID		ENSG00000173372	ENSG00000159189
Uniprot IDs		P02745	A0A024RAA7 A0A8Q3SIZ0 P02747
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U
GO Terms Enriched among Interactors		Complement Component C1q Complex Binding Complement Activation, Classical Pathway Complement Component C1 Complex Complement Activation Blood Microparticle Cell Surface Opsonization Immune Effector Process Positive Regulation Of ERAD Pathway Symbiont Cell Surface Defense Response To Symbiont Defense Response To Other Organism Regulation Of ERAD Pathway Innate Immune Response Regulation Of Protein Metabolic Process Extracellular Region Response To Stress Humoral Immune Response Virion Binding Activation Of Immune Response Extracellular Matrix Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To External Biotic Stimulus Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Defense Response Response To Other Organism Negative Regulation By Host Of Viral Glycoprotein Metabolic Process TRC Complex Regulation Of Immune Response Immune Response Extracellular Space Identical Protein Binding Negative Regulation Of Endothelial Cell Migration Complement Component C1q Complex Positive Regulation Of Immune System Process Protein Targeting To ER Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Multicellular Organismal Development Establishment Of Protein Localization To Endoplasmic Reticulum IgM Binding Positive Regulation Of Proteolysis Negative Regulation Of Immune System Process Polyubiquitin Modification-dependent Protein Binding Acute-phase Response Positive Regulation Of Proteasomal Protein Catabolic Process Postsynapse	Complement Component C1q Complex IgM Binding Complement Component C1 Complex Synapse Pruning IgG Binding Symbiont Cell Surface Complement Activation, Classical Pathway Complement Activation Regulation Of Endocytosis Phosphatidylserine Binding Immune Effector Process Collagen Trimer Regulation Of Receptor Internalization Extracellular Matrix Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding Edg-2 Lysophosphatidic Acid Receptor Binding Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Vesicle-mediated Transport Regulation Of Receptor-mediated Endocytosis Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Cell Surface Innate Immune Response Ovarian Cumulus Expansion Negative Regulation Of Clathrin-dependent Endocytosis Defense Response To Symbiont Defense Response To Other Organism Extrinsic Component Of Postsynaptic Membrane Complement Component C1q Complex Binding Membrane Raft Localization Postsynapse FK506 Binding Virion Binding Synapse Organization Humoral Immune Response Neuron Remodeling Response To Yeast Host-mediated Suppression Of Viral Proces Negative Regulation Of Receptor Internalization Astrocyte Activation Negative Regulation Of Glycoprotein Metabolic Process Opsonization Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Response To Other Organism