TGM2 and GRN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TGM2	GRN
Description		transglutaminase 2	granulin precursor
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Vesicle Azurophil Granule Lumen Extracellular Exosome Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Protein-folding Chaperone Binding
	Biological Process	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance	Trophectodermal Cell Proliferation Blastocyst Hatching Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Embryo Implantation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Locomotory Exploration Behavior Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Positive Regulation Of Axon Regeneration Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Protein Stabilization Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Retina Development In Camera-type Eye Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Maintenance Of Synapse Structure Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Trophectodermal Cell Proliferation Lysosomal Protein Catabolic Process Positive Regulation Of Aspartic-type Peptidase Activity Regulation Of Lysosome Organization Positive Regulation Of Lysosome Organization
Pathways			Neutrophil degranulation
Drugs		Guanosine-5'-Diphosphate Hexylresorcinol
Diseases			Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS			Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Mild age-related type 2 diabetes ( 34737425) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)
Interacting Genes		72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B	88 interacting genes: ALG13 ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT31 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1B LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A LCE5A MBD1 MEOX2 NEDD8 NLK NUFIP2 OTX1 P4HB PCM1 PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SHANK3 SLC13A1 SLPI SMAD9 SMCP SNRNP48 SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1
Entrez ID		7052	2896
HPRD ID		01825	00733
Ensembl ID		ENSG00000198959	ENSG00000030582
Uniprot IDs		B4DIT7 B4DTN7 P21980	P28799
PDB IDs		1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4	1G26 2JYE 2JYT 2JYU 2JYV 6NUG 8T8R 8T8S
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process	Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development P-TEFb Complex Nuclear Matrix Identical Protein Binding
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