TGM2 and BNIP3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TGM2	BNIP3
Gene Name		transglutaminase 2	BCL2/adenovirus E1B 19kDa interacting protein 3
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Dendrite Integral Component Of Mitochondrial Outer Membrane Mitochondrial Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity GTPase Binding
	Biological Process	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	Response To Hypoxia Apoptotic Process Cell Death Granzyme-mediated Apoptotic Signaling Pathway Positive Regulation Of Autophagy Negative Regulation Of Mitochondrial Fusion Viral Process Mitochondrial Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Complex Disassembly Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Membrane Potential Regulation Of Mitochondrial Membrane Permeability Autophagic Cell Death Brown Fat Cell Differentiation Neuron Apoptotic Process Defense Response To Virus Response To Hyperoxia Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrial Outer Membrane Permeabilization Toxin Transport Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia
Pathways
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B	15 interactors: BCL2 BCL2L1 BNIP3L CD47 CLEC7A CLN8 FATE1 HIVEP1 KTN1 LDLRAD1 MAP1LC3B NCBP1 RHEB TGM2 TMEM11
Entrez ID		7052	664
HPRD ID		01825	04482
Ensembl ID		ENSG00000198959
Uniprot IDs		B4DIT7 F5H6P0 P21980	Q12983
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S	2J5D 2KA1 2KA2
Enriched GO Terms of Interacting Partners?		Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus	Mitochondrion Organization Mitochondrial Membrane Organization Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Apoptotic Mitochondrial Changes Response To Other Organism Negative Regulation Of Anoikis Response To Biotic Stimulus Regulation Of Anoikis Membrane Organization Mitochondrial Transport Release Of Cytochrome C From Mitochondria Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Endoplasmic Reticulum Calcium Ion Homeostasis Response To External Stimulus Positive Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Transport Positive Regulation Of Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Virus Endocytosis Response To Gamma Radiation Phagocytosis Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Death Negative Regulation Of Cellular PH Reduction CD8-positive, Alpha-beta T Cell Lineage Commitment Apoptotic Process In Bone Marrow Negative Regulation Of Retinal Cell Programmed Cell Death Ovarian Follicle Development Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Stress Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine L-glutamate Uptake Involved In Synaptic Transmission Negative Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Programmed Cell Death Positive Regulation Of Inflammatory Response Ovulation Cycle Process
Tagcloud ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	accepted atg autophagy biomedical carbohydrate comprehensive discovery distributed diverse elucidating families great interest interesting lectins modulating origin perspective pharmacological plant problems raf representative respect summarize thousands ubiquitously widely working
Tagcloud (Difference) ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	accepted atg autophagy biomedical carbohydrate comprehensive discovery distributed diverse elucidating families great interest interesting lectins modulating origin perspective pharmacological plant problems raf representative respect summarize thousands ubiquitously widely working
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