TGM2 and PLCD1

Number of citations of the paper that reports this interaction (PMID 10518533)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		TGM2	PLCD1
Gene Name		transglutaminase 2	phospholipase C, delta 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding	Phosphatidylserine Binding Phosphatidylinositol Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding GTPase Activating Protein Binding Phosphatidic Acid Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	Angiogenesis Phospholipid Metabolic Process Lipid Catabolic Process Intracellular Signal Transduction Regulation Of Cell Proliferation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Labyrinthine Layer Blood Vessel Development
Pathways			Synthesis of IP3 and IP4 in the cytosol Inositol phosphate metabolism
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B	8 interactors: APP CALM1 GAP43 KPNB1 PAXIP1 RALA RALB TGM2
Entrez ID		7052	5333
HPRD ID		01825	09073
Ensembl ID		ENSG00000198959	ENSG00000187091
Uniprot IDs		B4DIT7 F5H6P0 P21980	A8K8F9 P51178
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S
Enriched GO Terms of Interacting Partners?		Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus	Axon Choice Point Recognition Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition Regulation Of Filopodium Assembly Positive Regulation Of Cellular Component Biogenesis Response To External Stimulus Exocytosis Response To Stimulus Regulation Of Cellular Amino Acid Metabolic Process Platelet Degranulation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Regulation Of Exocyst Assembly Response To Radiation Positive Regulation Of Protein Metabolic Process Locomotion Regulation Of Cellular Ketone Metabolic Process Secretion By Cell Cytokinesis Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Synaptic Growth At Neuromuscular Junction Positive Regulation Of Autophagic Vacuole Assembly Regulation Of Exocyst Localization Positive Regulation Of Vacuole Organization Regulation Of Cell Projection Assembly Cellular Response To Growth Factor Stimulus Cell Recognition Vesicle-mediated Transport Wound Healing Chemotaxis Response To Growth Factor Secretion Collateral Sprouting In Absence Of Injury Regulation Of Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Exocytosis Response To Wounding Membrane Raft Localization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Protein Kinase Activity Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of High Voltage-gated Calcium Channel Activity
Tagcloud ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcb2 plce potentiate quiescent react transduction tuned umbilical upcoming
Tagcloud (Difference) ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	adapt beside bloodstream codify depend differently differs ec endothelium enzymes evidences excepting finely neuroendocrine neuropeptide npy phosphoinositide phospholipase pi plcb2 plce potentiate quiescent react transduction tuned umbilical upcoming
Tagcloud (Intersection) ?