TGM2 and GSTP1

Number of citations: 0 (PubMedID 9973324)
Data Source: HPRD (in vivo)

		TGM2	GSTP1
Name		transglutaminase 2	glutathione S-transferase pi 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Cytosol Vesicle Secretory Granule Lumen Extracellular Exosome TRAF2-GSTP1 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity	Glutathione Transferase Activity Glutathione Peroxidase Activity Fatty Acid Binding Protein Binding JUN Kinase Binding Toxic Substance Binding Transferase Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity S-nitrosoglutathione Binding Dinitrosyl-iron Complex Binding Nitric Oxide Binding
	Biological Process	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance	Negative Regulation Of Transcription By RNA Polymerase II Response To Reactive Oxygen Species Negative Regulation Of Acute Inflammatory Response Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Central Nervous System Development Response To Toxic Substance Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Oligodendrocyte Development Animal Organ Regeneration Response To Nutrient Levels Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation Response To L-ascorbic Acid Common Myeloid Progenitor Cell Proliferation Nitric Oxide Storage Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Negative Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Response To Ethanol Negative Regulation Of JNK Cascade Negative Regulation Of Fibroblast Proliferation Hepoxilin Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Cell-matrix Adhesion Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Smooth Muscle Cell Chemotaxis Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		None	Glutathione conjugation Detoxification of Reactive Oxygen Species Neutrophil degranulation Paracetamol ADME
Drugs		Guanosine-5'-Diphosphate Hexylresorcinol	Glutathione Troglitazone Clozapine Etacrynic acid Clomipramine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene S-Hydroxycysteine Cibacron Blue Glutathione sulfonic acid Glutathione disulfide Deoxycholic acid Deoxycholic acid S-(4-nitrobenzyl)glutathione 2-(N-morpholino)ethanesulfonic acid S-Hexylglutathione Canfosfamide Ezatiostat Exisulind S-NONYL-CYSTEINE S-(4-BROMOBENZYL)CYSTEINE Curcumin Dinitrochlorobenzene Hypericin Curcumin sulfate
Diseases		None	Prostate cancer
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Hip circumference adjusted for BMI ( 34021172 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		None recorded	2 novel interactors: MPHOSPH10 PTPN22
Interacting Genes		72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B	39 interacting genes: ADAMTSL4 APPBP2 CARD10 CEBPA CYSRT1 FANCC FBXO8 FHL5 HOXA1 KRT31 KRT33B KRT34 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-2 LRP2BP MAPK8 MLH1 MTUS2 NBPF19 NOTCH2NLA OGT PNO1 PRDX6 PTN RNF26 SCAF1 SH3GLB1 SUMO4 TGM1 TGM2 TRAF2 ZNF655
Entrez ID		7052	2950
HPRD ID		01825	00614
Ensembl ID		ENSG00000198959	ENSG00000084207
Uniprot IDs		B4DIT7 B4DTN7 P21980	P09211 V9HWE9
PDB IDs		1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4	10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5DAK 5DAL 5DCG 5DDL 5DJL 5DJM 5GSS 5J41 5JCW 5L6X 5X79 6AP9 6GSS 6LLX 6Y1E 7BIA 7GSS 7XBA 8GSS 9GSS
GO Terms Enriched among Interactors		Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Protein-glutamine Gamma-glutamyltransferase Activity