TGM2 and LTBP1

Number of citations: 66 (PubMedID 9060478)
Data Source: HPRD (in vitro)

		TGM2	LTBP1
Name		transglutaminase 2	latent transforming growth factor beta binding protein 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Microfibril Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity	Transforming Growth Factor Beta Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Growth Factor Binding Transforming Growth Factor Beta Binding Microfibril Binding Molecular Adaptor Activity Receptor Ligand Inhibitor Activity
	Biological Process	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sequestering Of TGFbeta In Extracellular Matrix Establishment Of Protein Localization To Extracellular Region
Pathways		None	Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Guanosine-5'-Diphosphate Hexylresorcinol	None
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Arthritis (juvenile idiopathic) ( 34101054 ) Carpal tunnel syndrome ( 30833571 ) Central corneal thickness ( 32528159 29760442 ) Diverticular disease ( 30177863 ) Height ( 28552196 31562340 19893584 20189936 20881960 23563607 25282103 25429064 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Immune response to smallpox vaccine (IL-6) ( 22610502 ) Intraocular pressure ( 29785010 29617998 29235454 ) Knee osteoarthritis ( 30374069 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Male-pattern baldness ( 28196072 ) Optic disc size ( 31809533 ) Rosacea symptom severity ( 29771307 ) Total cholesterol levels ( 33339817 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172 )
Novel Interactors		None recorded	3 novel interactors: CAD FOXN2 ZFP36L2
Interacting Genes		72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B	13 interacting genes: ATN1 CACNA1A FBN1 FBN2 FN1 HOXA1 HTRA1 IGFBP3 IGFBP5 ITGB5 NOTCH3 TGFB1 TGM2
Entrez ID		7052	4052
HPRD ID		01825	01039
Ensembl ID		ENSG00000198959	ENSG00000049323
Uniprot IDs		B4DIT7 B4DTN7 P21980	B7ZLY3 E7EV71 Q14766
PDB IDs		1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4	1KSQ
GO Terms Enriched among Interactors		Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process	Developmental Process Regulation Of Cell Differentiation Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Insulin-like Growth Factor Binding Protein Complex Anatomical Structure Formation Involved In Morphogenesis Insulin-like Growth Factor Ternary Complex Regulation Of Smooth Muscle Cell Proliferation Growth Factor Binding Lung Alveolus Development Animal Organ Development Insulin-like Growth Factor II Binding Cellular Response To Transforming Growth Factor Beta Stimulus Sequestering Of Extracellular Ligand From Receptor Carbohydrate Homeostasis Glucose Homeostasis Extracellular Region Response To Transforming Growth Factor Beta Extracellular Negative Regulation Of Signal Transduction Cellular Response To Insulin-like Growth Factor Stimulus Extracellular Matrix Constituent Conferring Elasticity Insulin-like Growth Factor Binding Female Pregnancy Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Tissue Development Microfibril Insulin-like Growth Factor I Binding Positive Regulation Of Smooth Muscle Cell Proliferation Cell Differentiation Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type B Pancreatic Cell Proliferation Endoplasmic Reticulum Lumen Response To Peptide Hormone Extracellular Matrix Structural Constituent Response To Growth Factor Anatomical Structure Morphogenesis Response To Hormone Extracellular Space Tube Formation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Glucocorticoid Embryonic Eye Morphogenesis Negative Regulation Of Cell Differentiation Cell Adhesion Mediated By Integrin Integrin Binding Fibronectin Binding