TGM2 and LTBP1

Number of citations of the paper that reports this interaction (PMID 9060478)
50

Data Source:
HPRD (in vitro)

		TGM2	LTBP1
Gene Name		transglutaminase 2	latent transforming growth factor beta binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Protein Complex
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding	Transforming Growth Factor Beta-activated Receptor Activity Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding Microfibril Binding
	Biological Process	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Matrix Organization Sequestering Of TGFbeta In Extracellular Matrix
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS			Height ( 20881960 19893584 23563607 20189936) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502)
Protein-Protein Interactions		55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B	9 interactors: ATN1 CACNA1A FBN1 FBN2 FN1 IGFBP3 ITGB5 TGFB1 TGM2
Entrez ID		7052	4052
HPRD ID		01825	01039
Ensembl ID		ENSG00000198959	ENSG00000049323
Uniprot IDs		B4DIT7 F5H6P0 P21980	B7ZLY3 Q14766
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S	1KSQ
Enriched GO Terms of Interacting Partners?		Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus	Extracellular Matrix Organization Extracellular Structure Organization Sequestering Of TGFbeta In Extracellular Matrix Developmental Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Endoderm Development Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Extracellular Negative Regulation Of Signal Transduction Anatomical Structure Development Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Anatomical Structure Morphogenesis Endodermal Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Myoblast Differentiation Positive Regulation Of Biomineral Tissue Development Salivary Gland Morphogenesis Regulation Of Cell Differentiation Peptide Cross-linking System Development Salivary Gland Development Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Cell Differentiation Endoderm Formation Exocrine System Development Exocytosis Regulation Of Cell Growth Regulation Of Signaling Cellular Component Assembly Platelet Degranulation Regulation Of Bone Mineralization Cellular Metal Ion Homeostasis Cerebellar Molecular Layer Development Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Cell Death Death Negative Regulation Of Signal Transduction Positive Regulation Of Muscle Cell Differentiation Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis
Tagcloud ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	besides bioactive bioinformatics btb btbd3 candidate connectivity cul3 degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Difference) ?		antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately	besides bioactive bioinformatics btb btbd3 candidate connectivity cul3 degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Intersection) ?