TGM2 and GCGR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TGM2	GCGR
Description		transglutaminase 2	glucagon receptor
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Guanyl-nucleotide Exchange Factor Activity Peptide Hormone Binding
	Biological Process	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance	Generation Of Precursor Metabolites And Energy Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Regulation Of Blood Pressure Cellular Response To Starvation Positive Regulation Of Gene Expression Glucose Homeostasis Response To Starvation Regulation Of Glycogen Metabolic Process Cellular Response To Glucagon Stimulus
Pathways			Glucagon signaling in metabolic regulation G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		Guanosine-5'-Diphosphate Hexylresorcinol	Glucagon Dasiglucagon
Diseases
GWAS			Hematocrit ( 32888494)
Interacting Genes		72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B	4 interacting genes: GCG GNAS TGM2 TP63
Entrez ID		7052	2642
HPRD ID		01825	00678
Ensembl ID		ENSG00000198959	ENSG00000215644
Uniprot IDs		B4DIT7 B4DTN7 P21980	P47871
PDB IDs		1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4	2A83 3CZF 4ERS 4L6R 4LF3 5EE7 5XEZ 6LMK 6LML 6WHC 6WPW 7V35 8FU6 8JIQ 8JIT 8JIU 8JRU 8JRV 8WG8 8YW5
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process	Cellular Response To Glucagon Stimulus Response To Glucagon Response To Catecholamine Cellular Response To Catecholamine Stimulus Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Survivin Complex Regulation Of Signal Transduction Bone Development Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Ectoderm And Mesoderm Interaction Epidermal Cell Division Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phagocytosis Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Glucagon Receptor Binding Gastric Inhibitory Polypeptide Receptor Binding Mu-type Opioid Receptor Binding Protein Deamination Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Serotonin Female Genitalia Morphogenesis Negative Regulation Of Mesoderm Development Regulation Of Epidermal Cell Division G Protein-coupled Receptor Signaling Pathway Signal Transduction Regulation Of Insulin Secretion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Division Positive Regulation Of Exit From Mitosis Cobalt Ion Binding Cellular Response To Peptide Hormone Stimulus Chemical Homeostasis Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Prostatic Bud Formation
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