TGM2 and ADAR

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TGM2	ADAR
Name		transglutaminase 2	adenosine deaminase RNA specific
Structure
GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Lumen Supraspliceosomal Complex
	Molecular Function	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity	DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance	Osteoblast Differentiation Hematopoietic Progenitor Cell Differentiation Immune System Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing RNA Processing MRNA Processing Protein Import Into Nucleus Protein Export From Nucleus Apoptotic Process Response To Virus Base Conversion Or Substitution Editing Erythrocyte Differentiation Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Response To Interferon-alpha Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis RISC Complex Assembly Hepatocyte Apoptotic Process Cellular Response To Virus Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Hepatocyte Apoptotic Process
Pathways		None	C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling PKR-mediated signaling
Drugs		Guanosine-5'-Diphosphate Hexylresorcinol	None
Diseases		None	Dyschromatosis symmetrica hereditaria
GWAS		No GWAS studies recorded	Apolipoprotein A1 levels ( 32203549 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Interleukin-6 levels ( 33517400 ) Lung cancer ( 28604730 ) Prostate cancer ( 23535732 ) Squamous cell lung carcinoma ( 28604730 )
Interacting Genes		72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B	10 interacting genes: CEBPA ERG HDLBP LINC00624 PTEN SMURF2 TGM2 UBE2I USP7 XPO1
Entrez ID		7052	103
HPRD ID		01825	07528
Ensembl ID		ENSG00000198959	ENSG00000160710
Uniprot IDs		B4DIT7 B4DTN7 P21980	A0AAQ5BGH8 P55265
PDB IDs		1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4	1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 2MDR 3F21 3F22 3F23 3IRQ 3IRR 5ZU1 5ZUO 5ZUP 7C0I 7ZJ1 7ZLQ 8GBC 8GBD
GO Terms Enriched among Interactors		Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process	Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of RNA Metabolic Process Nucleus Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Protein Deamination Cellular Response To Triglyceride Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Cellular Response To Serotonin RING-like Zinc Finger Domain Binding Symbiont-mediated Disruption Of Host Cell PML Body Sterol Metabolic Process Nucleoplasm Cholesterol Metabolic Process Negative Regulation Of Metabolic Process White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells SUMO Ligase Complex HLH Domain Binding Response To Triglyceride