TGM2 and PINK1

Number of citations of the paper that reports this interaction (PubMedID 25557247)
0

Data Source:
BioGRID (pull down)

		TGM2	PINK1
Description		transglutaminase 2	PTEN induced kinase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cytosol Cytoskeleton Membrane Axon Growth Cone Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection
	Molecular Function	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity	Nucleotide Binding Magnesium Ion Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase B Binding Protein-containing Complex Binding Metal Ion Binding C3HC4-type RING Finger Domain Binding Protein Serine Kinase Activity
	Biological Process	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance	Autophagy Of Mitochondrion Mitophagy Regulation Of Oxidative Phosphorylation Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Dopamine Secretion Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Protein Ubiquitination Respiratory Electron Transport Chain Hemopoiesis Positive Regulation Of Cell Migration Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Positive Regulation Of Catecholamine Secretion Cellular Response To Oxidative Stress Intracellular Signal Transduction TORC2 Signaling Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Catecholamine Secretion Protein Stabilization Establishment Of Localization In Cell Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Hypoxia Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Cellular Response To Toxic Substance Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Mitophagy Regulation Of Synaptic Vesicle Transport Negative Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Cristae Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Free Ubiquitin Chain Polymerization Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			PINK1-PRKN Mediated Mitophagy FOXO-mediated transcription of cell death genes
Drugs		Guanosine-5'-Diphosphate Hexylresorcinol
Diseases			Parkinson's disease (PD)
GWAS			Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B	23 interacting genes: APPL2 BAG2 BAG5 BCL2L1 CRLS1 DNM1L FBXO7 HSH2D MAP3K7 MARK2 NEAT1 PARK7 RNF31 SIAH1 SIAH3 SNCAIP SPATC1L TGM2 TOMM20 TOMM70 TRAF6 UBC UBE2M
Entrez ID		7052	65018
HPRD ID		01825	10514
Ensembl ID		ENSG00000198959	ENSG00000158828
Uniprot IDs		B4DIT7 B4DTN7 P21980	Q9BXM7
PDB IDs		1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4	9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process	Ubiquitin Protein Ligase Binding Mitochondrion Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Identical Protein Binding Mitochondrial Outer Membrane Regulation Of Inclusion Body Assembly Regulation Of Protein Stability Linear Polyubiquitin Binding Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Ubiquitin Conjugating Enzyme Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Ubiquitin-protein Transferase Activity Mitochondrion Targeting Sequence Binding Protein Localization To Mitochondrion Positive Regulation Of Defense Response Interleukin-17A-mediated Signaling Pathway Regulation Of Protein Targeting To Mitochondrion Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway TOM Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Autophagy Of Mitochondrion Interleukin-33-mediated Signaling Pathway Regulation Of Apoptotic Process Mitochondrial Outer Membrane Translocase Complex Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Positive Regulation Of Catabolic Process CD40 Signaling Pathway Positive Regulation Of Autophagy TRIF-dependent Toll-like Receptor Signaling Pathway CD40 Receptor Complex Regulation Of Mitochondrial Membrane Potential Regulation Of Intracellular Signal Transduction Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Establishment Of Protein Localization To Mitochondrion Protein Insertion Into Mitochondrial Outer Membrane Regulation Of Protein Localization Negative Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
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