TGM2 and SLC7A9

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TGM2	SLC7A9
Description		transglutaminase 2	solute carrier family 7 member 9
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane
	Molecular Function	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity	Protein Binding Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-cystine Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Peptide Antigen Binding Protein Heterodimerization Activity Broad Specificity Neutral L-amino Acid:basic L-amino Acid Antiporter Activity
	Biological Process	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance	Amino Acid Transmembrane Transport Amino Acid Transport Neutral Amino Acid Transport L-cystine Transport Transmembrane Transport Protein-containing Complex Assembly L-alpha-amino Acid Transmembrane Transport Basic Amino Acid Transmembrane Transport
Pathways			Basigin interactions Amino acid transport across the plasma membrane Defective SLC3A1 causes cystinuria (CSNU) Defective SLC7A9 causes cystinuria (CSNU)
Drugs		Guanosine-5'-Diphosphate Hexylresorcinol
Diseases			Cystinuria
GWAS			Chronic kidney disease ( 20383146) Creatinine levels ( 20383145 29403010 31015462) Estimated glomerular filtration rate ( 31015462 30604766) Fractional excretion of metabolites in chronic kidney disease ( 29545352) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 21572414) Urinary metabolites (H-NMR features) ( 24586186)
Interacting Genes		72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B	3 interacting genes: CREB3 HSPB1 TGM2
Entrez ID		7052	11136
HPRD ID		01825	04997
Ensembl ID		ENSG00000198959	ENSG00000021488
Uniprot IDs		B4DIT7 B4DTN7 P21980	P82251
PDB IDs		1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4	6LI9 6LID 6YUP 6YV1
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process	Response To Unfolded Protein Negative Regulation Of Protein Kinase C Signaling Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Regulation Of Catalytic Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemotaxis Protein Deamination Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Protein Kinase C Inhibitor Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Serotonin Regulation Of Chemotaxis Regulation Of Protein Kinase C Signaling Negative Regulation Of Apoptotic Signaling Pathway Salivary Gland Cavitation Release From Viral Latency Dopamine Secretion Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Protein ADP-ribosylation CCR1 Chemokine Receptor Binding Cellular Response To Dopamine Positive Regulation Of Mitochondrial Calcium Ion Concentration Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Vasculature Development Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Angiogenesis Anterograde Axonal Protein Transport Positive Regulation Of Catalytic Activity Regulation Of Apoptotic Cell Clearance Cellular Response To Cocaine Response To Dopamine Catecholamine Secretion CAMP Response Element Binding Protein Binding Endoplasmic Reticulum Branching Involved In Salivary Gland Morphogenesis Regulation Of Apoptotic Signaling Pathway Protein Transport Along Microtubule Contractile Muscle Fiber Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Translation Focal Adhesion
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