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TGM2 and RELA
Number of citations of the paper that reports this interaction (PubMedID
16951195
)
0
Data Source:
HPRD
(in vivo)
TGM2
RELA
Description
transglutaminase 2
RELA proto-oncogene, NF-kB subunit
Image
GO Annotations
Cellular Component
Chromatin
Nucleosome
Extracellular Region
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Matrix
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
Protein-containing Complex
NF-kappaB P50/p65 Complex
Synapse
NF-kappaB Complex
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
Protein-glutamine Gamma-glutamyltransferase Activity
Calcium Ion Binding
Protein Binding
GTP Binding
Peptidase Activity
Transferase Activity
Acyltransferase Activity
Hydrolase Activity
Metal Ion Binding
Protein-glutamine Glutaminase Activity
Peptide Serotonyltransferase Activity
Histone Serotonyltransferase Activity
Peptide Dopaminyltransferase Activity
Histone Dopaminyltransferase Activity
Peptide Noradrenalinyltransferase Activity
Peptide Histaminyltransferase Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Protein Kinase Binding
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Peptide Binding
Phosphate Ion Binding
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
NF-kappaB Binding
Ankyrin Repeat Binding
General Transcription Initiation Factor Binding
DNA-binding Transcription Factor Binding
Biological Process
Chromatin Remodeling
Proteolysis
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Gene Expression
Dopamine Secretion
Peptide Cross-linking
Protein Deamination
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Positive Regulation Of GTPase Activity
Positive Regulation Of Cell Adhesion
Positive Regulation Of Neurogenesis
Positive Regulation Of Small GTPase Mediated Signal Transduction
Protein Homooligomerization
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Bone Development
Branching Involved In Salivary Gland Morphogenesis
Salivary Gland Cavitation
Cellular Response To Cocaine
Cellular Response To Dopamine
Positive Regulation Of Sprouting Angiogenesis
Cellular Response To Serotonin
Regulation Of Apoptotic Cell Clearance
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cytokine Production
Liver Development
Hair Follicle Development
Defense Response To Tumor Cell
Response To Ischemia
Chromatin Organization
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Defense Response
Inflammatory Response
Cellular Defense Response
Neuropeptide Signaling Pathway
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Bacterium
Animal Organ Morphogenesis
Response To UV-B
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Positive Regulation Of Schwann Cell Differentiation
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Protein Catabolic Process
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Response To Progesterone
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Response To Insulin
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Protein Sumoylation
Response To Cobalamin
Response To Cytokine
Toll-like Receptor 4 Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Hepatocyte Growth Factor Stimulus
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Vascular Endothelial Growth Factor Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Prolactin Signaling Pathway
Negative Regulation Of Protein Catabolic Process
Response To Hydrogen Peroxide
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Response To Morphine
Innate Immune Response
Response To Ethanol
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Inflammatory Response
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To CAMP
Defense Response To Virus
Cellular Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Peptidoglycan
Cellular Response To Nicotine
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Postsynapse To Nucleus Signaling Pathway
Antiviral Innate Immune Response
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Amyloid-beta Formation
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Cellular Response To Angiotensin
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of MiRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1-dependent IKK and NF-kappa-B activation
Interleukin-1 processing
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
Regulation of NFE2L2 gene expression
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Drugs
Guanosine-5'-Diphosphate
Hexylresorcinol
Glucosamine
Dimethyl fumarate
SC-236
Diseases
GWAS
Acne (severe) (
24927181
)
Asthma (
31619474
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Inflammatory bowel disease (
23128233
)
LDL cholesterol levels (
32203549
)
Sensation seeking (
30718321
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Urate levels (
31578528
31985003
)
Interacting Genes
72 interacting genes:
A2M
ABCA1
ACTB
ADAR
ALDOA
ANKRD28
ANXA1
APP
ARNT
ATF4
BNIP3
C3
CASP3
CBL
CERT1
COL11A1
COL18A1
COL1A1
COL4A1
COL6A1
CSNK2A2
EIF5A
FN1
FNDC3B
FNTA
GCGR
GRN
GSTP1
H2BC21
H2BC8
HMGB1
HNRNPF
HNRNPUL1
HP
HSPA1A
HSPA1B
HSPA8
HTT
ITGAV
ITGB1
ITGB3
KPNA3
KPNA4
LACRT
LAMA1
LTBP1
MAP3K12
MMP14
PAK1
PELI2
PINK1
PLCD1
PPHLN1
PXN
RB1
RELA
RHOA
S100A7
SERPINF2
SERTAD1
SIPA1L2
SLC7A9
SMAD2
SMAD3
SNCA
SPARC
TAB2
THBS1
TMEM176A
TMSB4X
TUBB
ZNF512B
205 interacting genes:
AATF
ACTL6A
AGO1
AHR
AKAP8
APBA2
AR
ARNT
ASB9
AURKA
BANP
BATF2
BRCA1
BRMS1
BTK
BTRC
C1QB
CALM1
CAMK4
CARM1
CCL5
CCND2
CDC34
CDK9
CEBPB
CEBPD
CHEK1
CHUK
CNNM3
COL2A1
COMMD1
COMMD10
CREBBP
CSNK1G1
CSNK2A1
CSNK2A2
DDC
DDX1
DHX9
DNAJA3
DNMT3L
ECSIT
EEF1D
EGR1
EP300
EPHA2
ESR1
ETHE1
EZH2
FAF1
FBP1
FBXW2
FKBP11
FOS
FUS
GLIS1
GOPC
GTF2B
HDAC1
HDAC2
HDAC3
HEXIM1
HMGA2
HMGB1
HSPA4
IGF1R
IKBKB
IKBKE
ING4
IRAK1BP1
IRF1
IRF2
IRF3
IRF8
IRF9
ISL1
JUN
KAT2A
KAT2B
KAT5
KDM2A
KEAP1
KPNA2
LATS2
LMO2
MAP2K6
MAP3K7
MAP3K8
MAPK10
MAPK14
MED15
MED23
MED7
MEN1
MEOX2
MKRN2
MST1R
MTPN
MX1
MYC
NCOA3
NCOA6
NCOR2
NFE2L2
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NKRF
NKX2-1
NOTCH1
NPM1
NR3C1
OVOL2
PARP1
PDCD11
PGR
PIAS1
PIAS3
PIK3CA
PIN1
PKM
PLA2G4A
PLK1
PML
POU2F1
POU6F2
PPARA
PPP1R13L
PPP2CA
PPP2CB
PPP2R1B
PPP4C
PRKACA
PRKCZ
PRMT1
PRTN3
PSMD10
RAD51
RASSF1
RBCK1
REL
RELB
REPS2
RFC1
RIOK2
RNASE1
RNF25
RPL13
RPL23
RPS3
RPS6KA5
RTN4IP1
RXRA
SAT1
SETD7
SIN3A
SIRT1
SMAD3
SNIP1
SNRNP70
SOCS1
SOCS6
SORD
SP1
SRF
STAT1
STAT3
STAT6
SUOX
TAF1
TAF11
TAF4B
TAF6
TAF9
TBK1
TBP
TCAP
TCF4
TERT
TGM2
TLE5
TNIP2
TP53
TP53BP1
TP53BP2
TRIB3
TRIM55
TRIM63
TRIP4
TSC22D3
TWIST1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBE2L3
UNC5CL
USF2
USP7
ZBTB7A
ZBTB7B
Entrez ID
7052
5970
HPRD ID
01825
01241
Ensembl ID
ENSG00000198959
ENSG00000173039
Uniprot IDs
B4DIT7
B4DTN7
P21980
A0A087X0W8
Q04206
PDB IDs
1KV3
2Q3Z
3LY6
3S3J
3S3P
3S3S
4PYG
6A8P
6KZB
8TR9
9BC2
9BC3
9BC4
1NFI
2LSP
2O61
3GUT
3QXY
3RC0
4KV1
4KV4
5U4K
5URN
6NV2
6QHL
6QHM
6YOW
6YOX
6YOY
6YP2
6YP3
6YP8
6YPL
6YPY
6YQ2
7BI3
7BIQ
7BIW
7BIY
7BJB
7BJF
7BJL
7BJW
7BKH
7LET
7LEU
7LF4
7NJ9
7NJB
7NK3
7NK5
7NLA
7NLE
7NM1
7NM3
7NM9
7NMH
7NQP
7NR7
7NSV
7NV4
7NVI
7NWS
7NXS
7NXT
7NXW
7NXY
7NY4
7NYE
7NYF
7NYG
7NZ6
7NZG
7NZK
7NZV
7O34
7O3A
7O3F
7O3P
7O3Q
7O3R
7O3S
7O57
7O59
7O5A
7O5C
7O5D
7O5F
7O5G
7O5O
7O5P
7O5S
7O5U
7O5X
7O6F
7O6G
7O6I
7O6J
7O6K
7O6M
7O6O
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Response To Oxidative Stress
Response To Stress
Positive Regulation Of Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Cell Migration
Regulation Of Programmed Cell Death
Positive Regulation Of Cell Motility
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Locomotion
Positive Regulation Of Developmental Process
Regulation Of Intracellular Signal Transduction
Protease Binding
Regulation Of Protein Metabolic Process
Regulation Of Cellular Component Organization
Extracellular Matrix
Regulation Of Locomotion
Platelet Alpha Granule Lumen
Regulation Of Cell Differentiation
Regulation Of Cell Migration
Signal Transduction
Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway
Extracellular Space
Regulation Of Cell Motility
Regulation Of Defense Response
Apolipoprotein A-I-mediated Signaling Pathway
Response To Reactive Oxygen Species
C3HC4-type RING Finger Domain Binding
Response To External Biotic Stimulus
Blood Microparticle
Positive Regulation Of Cell Differentiation
Focal Adhesion
Regulation Of Immune System Process
Response To Lipid
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Cellular Component Organization
Response To Hormone
Regulation Of Cell Population Proliferation
Negative Regulation Of Signal Transduction
Extracellular Region
Regulation Of Apoptotic Signaling Pathway
Enzyme Binding
Regulation Of Phosphorus Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Nucleus
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Response To Stress
Chromatin
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Macromolecule Metabolic Process
DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
Transcription Cis-regulatory Region Binding
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Chromatin Remodeling
Rhythmic Process
Negative Regulation Of Signal Transduction
Nucleic Acid Metabolic Process
Cytosol
Negative Regulation Of Signaling
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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