ACP5 and EGR2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ACP5	EGR2
Description		acid phosphatase 5, tartrate resistant	early growth response 2
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Cytosol Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Acid Phosphatase Activity Ferrous Iron Binding Ferric Iron Binding Hydrolase Activity Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Nitric Oxide Biosynthetic Process Negative Regulation Of Macrophage Cytokine Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Superoxide Anion Generation Response To Cytokine Superoxide Anion Generation Negative Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Negative Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Bone Morphogenesis	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Brain Development Peripheral Nervous System Development Rhythmic Behavior Motor Neuron Axon Guidance Gene Expression Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation Protein Sumoylation Rhombomere 3 Development Facial Nerve Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Structural Organization Rhombomere 5 Formation Regulation Of Ossification Positive Regulation Of Myelination Brain Segmentation Aorta Development Skeletal Muscle Cell Differentiation Myelination Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Vitamin B2 (riboflavin) metabolism	Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood protein levels ( 30072576) Multiple sclerosis (severity) ( 19010793)	Adventurousness ( 30643258) Alopecia areata ( 25608926) Atopic dermatitis ( 23042114) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Ewing sarcoma ( 22327514) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Monocyte percentage of white cells ( 32888494) Selective IgA deficiency ( 27723758) Temperament ( 22832960) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Vogt-Koyanagi-Harada syndrome ( 25108386)
Interacting Genes		12 interacting genes: BCL2L13 EGR2 GPC4 MAPK9 PDCD5 PPP2CB RPA2 SLC35F6 SNRNP40 SPP1 TNFSF10 ZBTB16	21 interacting genes: ACP5 BPGM DNMT3L GOLGA2 HCFC1 JPT2 MCRS1 MED31 NAB2 NDUFS2 NFATC1 PDE4DIP RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WEE2-AS1 WWP2
Entrez ID		54	1959
HPRD ID		01374	00551
Ensembl ID		ENSG00000102575	ENSG00000122877
Uniprot IDs		P13686	A0A8I5KYI5 P11161
PDB IDs		1WAR 2BQ8
Enriched GO Terms of Interacting Partners?		Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Mitochondrion Organization Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Negative Regulation Of Nucleobase-containing Compound Metabolic Process NSL Complex Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Enteric Nervous System Development Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Glial Cell Differentiation Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Complex Positive Regulation Of RNA Biosynthetic Process MLL1 Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Development Negative Regulation Of Myoblast Differentiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Superoxide Anion Generation Positive Regulation Of RNA Metabolic Process SUMO Conjugating Enzyme Activity Citrate-L-glutamate Ligase Activity N-acetyl-L-aspartate-L-glutamate Ligase Activity Oligodendrocyte Differentiation DNA-binding Transcription Factor Binding Regulation Of Gene Expression Centrosome Cycle
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