MARCKS and CTSB

Number of citations of the paper that reports this interaction (PubMedID 9295331)
0

Data Source:
HPRD (in vitro)

		MARCKS	CTSB
Description		myristoylated alanine rich protein kinase C substrate	cathepsin B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Actin Cytoskeleton Membrane Nuclear Speck Cell Junction Actin Filament Bundle Germinal Vesicle Organelle Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Endolysosome Lumen Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Peptidase Inhibitor Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Actin Binding Protein Kinase C Binding Calmodulin Binding Identical Protein Binding Actin Filament Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteoglycan Binding
	Biological Process	Apoptotic Process Mitochondrion Organization Actin Filament Organization Central Nervous System Development Neural Tube Development Neurogenesis Response To Endoplasmic Reticulum Stress Actin Filament Bundle Assembly Actin Crosslink Formation	Proteolysis Thyroid Hormone Generation Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Decidualization Symbiont Entry Into Host Cell Proteolysis Involved In Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Acetylcholine regulates insulin secretion	Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation Degradation of CDH1
Drugs			2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases			Tropical calcific pancreatitis
GWAS		Alcohol dependence ( 33290381) Bipolar disorder (body mass index interaction) ( 24322204) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Household income ( 31844048) Household income (MTAG) ( 31844048) Type 2 diabetes ( 25760438)	A body shape index ( 34021172) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) Dilated cardiomyopathy (MTAG) ( 33495596) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 28892059 32201043) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Processed meat consumption ( 32066663) Refractive error ( 32231278) Triglyceride levels ( 29083408) Triglycerides ( 30275531) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		11 interacting genes: CALM2 CCNE1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB SPP1 TOB1	40 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD DSCR9 ERCC6 FAM118B HNRNPD HSPB2 IGF1 INS LCOR LINC00632 MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1
Entrez ID		4082	1508
HPRD ID		07519	00287
Ensembl ID		ENSG00000277443	ENSG00000164733
Uniprot IDs		P29966 Q6NVI1	A0A024R374 P07858
PDB IDs			1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2 8B4T 8B5F 8HE9 8HEI 8HEN
Enriched GO Terms of Interacting Partners?		Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Kinase Activity Cyclin E1-CDK2 Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Phosphorylation Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Protein Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Nuclear Membrane Disassembly Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Bone Resorption Nuclear Membrane Disassembly Membrane Disassembly Calyx Of Held Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Hormone Secretion Decidualization Nuclear Androgen Receptor Binding Presynaptic Cytosol Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Regulation Of Mitotic Cell Cycle Protein Modification Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Hormone Levels Regulation Of Bone Resorption Regulation Of Cell Cycle Transferase Activity Response To Ketone Regulation Of Bone Remodeling Calcium Channel Regulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase C Binding Nuclear Membrane Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Hormone Secretion Chromatin Remodeling Cell Cycle G2/M Phase Transition Myristoyltransferase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Metabolic Process Extracellular Space Extracellular Matrix Negative Regulation Of Macromolecule Metabolic Process Extracellular Region Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Serine-type Endopeptidase Inhibitor Activity Regulation Of Phosphorus Metabolic Process Receptor Ligand Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance AnxA2-p11 Complex Lipoprotein Particle Cellular Response To Amyloid-beta Insulin-like Growth Factor Receptor Binding Regulation Of Plasminogen Activation Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process Response To Amyloid-beta Positive Regulation Of Multicellular Organismal Process Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Phosphorylation Endosome Lumen Insulin Receptor Binding Positive Regulation Of Glycolytic Process Response To UV-B Regulation Of Protein Catabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphorylation Regulation Of Metabolic Process Regulation Of ATP Metabolic Process Response To Alcohol Cellular Developmental Process Response To UV Extracellular Exosome Positive Regulation Of Plasma Membrane Repair Calcium-dependent Protein Binding
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