MARCKS and CCNE1

Number of citations of the paper that reports this interaction (PMID 10359664)
5

Data Source:
BioGRID (enzymatic study)

		MARCKS	CCNE1
Gene Name		myristoylated alanine-rich protein kinase C substrate	cyclin E1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Germinal Vesicle Extracellular Vesicular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Kinase C Binding Calmodulin Binding Actin Filament Binding	Transcription Coactivator Activity Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Androgen Receptor Binding
	Biological Process	Energy Reserve Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Protein Phosphorylation Wnt Signaling Pathway Androgen Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle
Pathways		Acetylcholine regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion	E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Cellular Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes p53-Dependent G1/S DNA damage checkpoint G0 and Early G1 S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic p53-Dependent G1 DNA Damage Response SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1/S-Specific Transcription Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS			Bladder cancer ( 20972438)
Protein-Protein Interactions		13 interactors: CALM2 CCNE1 CDK1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB PRKCZ SPP1 TOB1	46 interactors: AR ARHGEF5 ARID4A BRCA2 BTRC CABLES1 CALM1 CCT4 CDC25A CDC34 CDC6 CDK1 CDK2 CDK3 CDKN1A COIL CUL3 FBXW7 FOXM1 GSK3B H1F0 HERC5 HIST1H1A HIST1H1B MARCKS MCM3 MRE11A MYBL2 NBN PIN1 POLD1 PRC1 PRKAR1A RB1 RBL1 RBL2 RBX1 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 TP73 UBTF
Entrez ID		4082	898
HPRD ID		07519	00455
Ensembl ID		ENSG00000155130	ENSG00000105173
Uniprot IDs		P29966	P24864
PDB IDs			1W98
Enriched GO Terms of Interacting Partners?		Histone Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-threonine Phosphorylation Regulation Of Protein Kinase Activity Phosphorylation Regulation Of Kinase Activity Cellular Response To Stimulus Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Metabolic Process Histone H3-T6 Phosphorylation Regulation Of Rhodopsin Mediated Signaling Pathway Signaling Cell Communication Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Rhodopsin Mediated Signaling Pathway Mitotic Cell Cycle Process Response To Stress Mitotic Nuclear Envelope Disassembly Response To Wounding Positive Regulation Of Cellular Metabolic Process Chromatin Organization Response To Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Intracellular Signal Transduction Mitotic Cell Cycle Histone Modification Nuclear Envelope Disassembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Blood Coagulation Hemostasis Phosphate-containing Compound Metabolic Process Platelet Activation Regulation Of Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Response To Hormone Peptidyl-amino Acid Modification Nuclear Envelope Organization Positive Regulation Of Phospholipase Activity Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Response To Insulin Stimulus Chromosome Organization Mitotic Cell Cycle Phase Transition	Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Organelle Organization Chromosome Organization Positive Regulation Of Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression DNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Cell Cycle Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process DNA Replication Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cell Division Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Modification Cell Cycle Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Phase Transition
Tagcloud ?		approximate brainstem bulb ca1 ca3 callosum cerebellar corpus cortices declined entorhinal filamentous fimbria fornix granule habenula hilus medial mrp myristoylated neocortex olfactory p1 p14 p7 phosphoproteins purkinje thalamus thirds	augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology
Tagcloud (Difference) ?		approximate brainstem bulb ca1 ca3 callosum cerebellar corpus cortices declined entorhinal filamentous fimbria fornix granule habenula hilus medial mrp myristoylated neocortex olfactory p1 p14 p7 phosphoproteins purkinje thalamus thirds	augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology
Tagcloud (Intersection) ?