MARCKS and SPP1

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		MARCKS	SPP1
Gene Name		myristoylated alanine-rich protein kinase C substrate	secreted phosphoprotein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Germinal Vesicle Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase C Binding Calmodulin Binding Actin Filament Binding	Cytokine Activity Protein Binding Extracellular Matrix Binding
	Biological Process	Energy Reserve Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Pathways		Acetylcholine regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion	Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Dental caries ( 23064961)
Protein-Protein Interactions		13 interactors: CALM2 CCNE1 CDK1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB PRKCZ SPP1 TOB1	88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		4082	6696
HPRD ID		07519	01325
Ensembl ID		ENSG00000155130	ENSG00000118785
Uniprot IDs		P29966	B7Z351 P10451 Q3LGB0
PDB IDs			3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Histone Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-threonine Phosphorylation Regulation Of Protein Kinase Activity Phosphorylation Regulation Of Kinase Activity Cellular Response To Stimulus Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Metabolic Process Histone H3-T6 Phosphorylation Regulation Of Rhodopsin Mediated Signaling Pathway Signaling Cell Communication Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Rhodopsin Mediated Signaling Pathway Mitotic Cell Cycle Process Response To Stress Mitotic Nuclear Envelope Disassembly Response To Wounding Positive Regulation Of Cellular Metabolic Process Chromatin Organization Response To Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Intracellular Signal Transduction Mitotic Cell Cycle Histone Modification Nuclear Envelope Disassembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Blood Coagulation Hemostasis Phosphate-containing Compound Metabolic Process Platelet Activation Regulation Of Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Response To Hormone Peptidyl-amino Acid Modification Nuclear Envelope Organization Positive Regulation Of Phospholipase Activity Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Response To Insulin Stimulus Chromosome Organization Mitotic Cell Cycle Phase Transition See more	Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process See more
Tagcloud ?		approximate brainstem bulb ca1 ca3 callosum cerebellar corpus cortices declined entorhinal filamentous fimbria fornix granule habenula hilus medial mrp myristoylated neocortex olfactory p1 p14 p7 phosphoproteins purkinje thalamus thirds	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Difference) ?		approximate brainstem bulb ca1 ca3 callosum cerebellar corpus cortices declined entorhinal filamentous fimbria fornix granule habenula hilus medial mrp myristoylated neocortex olfactory p1 p14 p7 phosphoproteins purkinje thalamus thirds	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Intersection) ?