NCSTN and APH1A

Number of citations of the paper that reports this interaction (PubMedID 12857757)
0

Data Source:
HPRD (in vitro, in vivo)

		NCSTN	APH1A
Description		nicastrin	aph-1A gamma-secretase subunit
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Focal Adhesion Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Azurophil Granule Membrane Sarcolemma Melanosome Presynaptic Membrane Extracellular Exosome Gamma-secretase Complex Synaptic Membrane Secretory Vesicle	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Golgi Cisterna Membrane Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane
	Molecular Function	Endopeptidase Activity Protein Binding Peptidase Activity Protein-macromolecule Adaptor Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving ATPase Binding Endopeptidase Activator Activity Growth Factor Receptor Binding	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis G Protein-coupled Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Learning Or Memory Protein Processing Cerebellum Development Central Nervous System Myelination Adult Behavior Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation T Cell Proliferation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid Precursor Protein Catabolic Process Amyloid-beta Metabolic Process Epithelial Cell Proliferation Neuron Apoptotic Process Cellular Response To Calcium Ion Regulation Of Long-term Synaptic Potentiation Short-term Synaptic Potentiation	Metanephros Development Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process
Pathways		Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs			E-2012 MK-0752
Diseases		Acne inversa; Hidradenitis supprativa
GWAS		Post bronchodilator FEV1 in COPD ( 26634245)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26835600 26955885) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: ABL1 APH1A APH1B APP BACE1 MAPK9 PSEN1 PSEN2 PSENEN SPP1 TMED10	36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1
Entrez ID		23385	51107
HPRD ID		05584	06360
Ensembl ID		ENSG00000162736	ENSG00000117362
Uniprot IDs		A0A8V8TPQ8 A0A8V8TPR8 B4DR82 Q92542	B4DUG7 Q96BI3
PDB IDs		2N7Q 2N7R 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8OQY 8OQZ 8X52 8X53 8X54	5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8X52 8X53 8X54
Enriched GO Terms of Interacting Partners?		Gamma-secretase Complex Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Notch Receptor Processing Membrane Protein Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Protein Processing Protein Maturation Membrane Protein Intracellular Domain Proteolysis Synaptic Membrane Enzyme Binding Positive Regulation Of Proteolysis Endopeptidase Activator Activity Modulation Of Chemical Synaptic Transmission Golgi Apparatus Protein Metabolic Process Endoplasmic Reticulum Early Endosome Presynaptic Membrane Synaptic Vesicle Golgi Membrane Astrocyte Activation Involved In Immune Response Neuron Projection Organization Plasma Membrane Regulation Of Proteolysis Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Cellular Response To Amyloid-beta Negative Regulation Of Axonogenesis Aspartic Endopeptidase Activity, Intramembrane Cleaving Response To Amyloid-beta Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cytokine Production Cellular Response To Manganese Ion Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Learning Or Memory Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Transport Neuron Projection Maintenance Endoplasmic Reticulum Membrane Endosome Membrane Signal Transduction	Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Amyloid Precursor Protein Metabolic Process Presynaptic Membrane Membrane Protein Proteolysis Notch Signaling Pathway Cajal-Retzius Cell Differentiation Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Cell Surface Receptor Signaling Pathway Growth Factor Receptor Binding Regulation Of Transport Adenohypophysis Development Positive Regulation Of Growth Hormone Secretion Membrane CAMP Response Element Binding Protein Binding Regulation Of Protein Metabolic Process Negative Regulation Of Transport Homeostatic Process Regulation Of Growth Hormone Secretion Membrane Protein Intracellular Domain Proteolysis Golgi Membrane Synaptic Membrane Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Signal Transduction Vesicle Targeting Epithelial Cell Proliferation Protein Processing Endopeptidase Activator Activity Regulation Of Primary Metabolic Process Regulation Of Synaptic Plasticity G Protein-coupled Dopamine Receptor Signaling Pathway Cerebral Cortex Neuron Differentiation
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