NCSTN

Gene Name		nicastrin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Integral Component Of Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Activity Protein Binding
	Biological Process	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Membrane Protein Intracellular Domain Proteolysis T Cell Proliferation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Beta-amyloid Metabolic Process Epithelial Cell Proliferation Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Degradation of the extracellular matrix Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-protein Interactions		10 interactors: ABL1 APH1A APH1B APP BACE1 PSEN1 PSEN2 PSENEN SPP1 TMED10
Entrez ID		23385
HPRD ID		05584
Ensembl ID		ENSG00000162736
Uniprot IDs		F6Y097 Q92542
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Proteolysis Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Amyloid Precursor Protein Catabolic Process Notch Signaling Pathway Amyloid Precursor Protein Metabolic Process Membrane Protein Intracellular Domain Proteolysis Chemotaxis Locomotion Axon Guidance Movement Of Cell Or Subcellular Component Generation Of Neurons Neuron Development Apoptotic Process Protein Processing Neurogenesis Axonogenesis Programmed Cell Death Beta-amyloid Metabolic Process Cell Death Death Axon Development Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Response To External Stimulus Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Death Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Morphogenesis Involved In Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Nervous System Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Thymus Development Neurotrophin TRK Receptor Signaling Pathway Collateral Sprouting System Development Regulation Of Protein Tyrosine Kinase Activity Cell Morphogenesis Cell Development Neurotrophin Signaling Pathway Cell Projection Organization
Tagcloud ?		achieve apoe bace1 classifiers classify cure decision discussion extremely fairly gradual incipient informative judgement language mapt meta mini mmse neurofibrillary nft onset orientation psen1 psen2 stages tangles tau trees