NCSTN and APH1B

Number of citations of the paper that reports this interaction (PMID 12857757)
54

Data Source:
HPRD (in vivo, in vitro)

		NCSTN	APH1B
Gene Name		nicastrin	APH1B gamma secretase subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Integral Component Of Membrane Melanosome Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane Transport Vesicle
	Molecular Function	Endopeptidase Activity Protein Binding	Protein Binding Peptidase Activity
	Biological Process	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Membrane Protein Intracellular Domain Proteolysis T Cell Proliferation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Beta-amyloid Metabolic Process Epithelial Cell Proliferation Apoptotic Signaling Pathway	Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Degradation of the extracellular matrix Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants	Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ABL1 APH1A APH1B APP BACE1 PSEN1 PSEN2 PSENEN SPP1 TMED10	3 interactors: NCSTN PSEN1 PSEN2
Entrez ID		23385	83464
HPRD ID		05584	06361
Ensembl ID		ENSG00000162736	ENSG00000138613
Uniprot IDs		F6Y097 Q92542	Q8WW43
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Proteolysis Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Amyloid Precursor Protein Catabolic Process Notch Signaling Pathway Amyloid Precursor Protein Metabolic Process Membrane Protein Intracellular Domain Proteolysis Chemotaxis Locomotion Axon Guidance Movement Of Cell Or Subcellular Component Generation Of Neurons Neuron Development Apoptotic Process Protein Processing Neurogenesis Axonogenesis Programmed Cell Death Beta-amyloid Metabolic Process Cell Death Death Axon Development Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Response To External Stimulus Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Death Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Morphogenesis Involved In Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Nervous System Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Thymus Development Neurotrophin TRK Receptor Signaling Pathway Collateral Sprouting System Development Regulation Of Protein Tyrosine Kinase Activity Cell Morphogenesis Cell Development Neurotrophin Signaling Pathway Cell Projection Organization	Amyloid Precursor Protein Catabolic Process Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Notch Signaling Pathway Peptide Metabolic Process Protein Processing Cellular Amide Metabolic Process Membrane Protein Intracellular Domain Proteolysis T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Dorsal/ventral Neural Tube Patterning Lymphocyte Activation Positive Regulation Of Coagulation Brain Morphogenesis Leukocyte Activation Single Organismal Cell-cell Adhesion Thymus Development Neural Tube Patterning Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death T Cell Activation Involved In Immune Response Cell Activation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Somitogenesis Epithelial Cell Proliferation Cell Fate Specification Somite Development Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Myeloid Leukocyte Differentiation Segmentation Regulation Of Receptor Activity Neuron Development Apoptotic Process Dorsal/ventral Pattern Formation Memory Programmed Cell Death
Tagcloud ?		achieve apoe bace1 classifiers classify cure decision discussion extremely fairly gradual incipient informative judgement language mapt meta mini mmse neurofibrillary nft onset orientation psen1 psen2 stages tangles tau trees	abeta abeta38 abeta40 addressed advance affects attributes carboxypeptidase catalytic complexes discriminate dissociated dissociation endopeptidase favoring gamma generation intrinsic produces protease psen2 qualitative questions retains secretase signature valid validation
Tagcloud (Difference) ?		achieve apoe bace1 classifiers classify cure decision discussion extremely fairly gradual incipient informative judgement language mapt meta mini mmse neurofibrillary nft onset orientation psen1 stages tangles tau trees	abeta abeta38 abeta40 addressed advance affects attributes carboxypeptidase catalytic complexes discriminate dissociated dissociation endopeptidase favoring gamma generation intrinsic produces protease qualitative questions retains secretase signature valid validation
Tagcloud (Intersection) ?		psen2