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NCSTN and APH1B
Number of citations of the paper that reports this interaction (PubMedID
12857757
)
0
Data Source:
HPRD
(in vitro, in vivo)
NCSTN
APH1B
Description
nicastrin
aph-1B gamma-secretase subunit
Image
GO Annotations
Cellular Component
Golgi Membrane
Lysosome
Lysosomal Membrane
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Focal Adhesion
Synaptic Vesicle
Endosome Membrane
Endomembrane System
Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Protein-containing Complex
Azurophil Granule Membrane
Sarcolemma
Melanosome
Presynaptic Membrane
Extracellular Exosome
Gamma-secretase Complex
Synaptic Membrane
Secretory Vesicle
Golgi Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Endosome Membrane
Membrane
Transport Vesicle
Gamma-secretase Complex
Molecular Function
Endopeptidase Activity
Protein Binding
Peptidase Activity
Protein-macromolecule Adaptor Activity
Aspartic Endopeptidase Activity, Intramembrane Cleaving
ATPase Binding
Endopeptidase Activator Activity
Growth Factor Receptor Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Endopeptidase Activator Activity
Biological Process
Myeloid Cell Homeostasis
Proteolysis
Membrane Protein Ectodomain Proteolysis
G Protein-coupled Dopamine Receptor Signaling Pathway
Glutamate Receptor Signaling Pathway
Notch Signaling Pathway
Notch Receptor Processing
Learning Or Memory
Protein Processing
Cerebellum Development
Central Nervous System Myelination
Adult Behavior
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
T Cell Proliferation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Biosynthetic Process
Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process
Amyloid Precursor Protein Catabolic Process
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Neuron Apoptotic Process
Cellular Response To Calcium Ion
Regulation Of Long-term Synaptic Potentiation
Short-term Synaptic Potentiation
Proteolysis
Notch Signaling Pathway
Notch Receptor Processing
Protein Processing
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
Amyloid Precursor Protein Catabolic Process
Pathways
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Amyloid fiber formation
TGFBR3 PTM regulation
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Amyloid fiber formation
TGFBR3 PTM regulation
Drugs
Diseases
Acne inversa; Hidradenitis supprativa
GWAS
Post bronchodilator FEV1 in COPD (
26634245
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Estimated glomerular filtration rate (
31152163
)
Family history of Alzheimer's disease (
30617256
)
Metabolite levels (
23823483
)
Myopia (
27182965
)
Refractive error (
32231278
)
Response to fenofibrate (triglyceride levels) (
27002377
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Interacting Genes
11 interacting genes:
ABL1
APH1A
APH1B
APP
BACE1
MAPK9
PSEN1
PSEN2
PSENEN
SPP1
TMED10
7 interacting genes:
FXYD6-FXYD2
NCSTN
PSEN1
PSEN2
TM4SF4
TRARG1
VSTM1
Entrez ID
23385
83464
HPRD ID
05584
06361
Ensembl ID
ENSG00000162736
ENSG00000138613
Uniprot IDs
A0A8V8TPQ8
A0A8V8TPR8
B4DR82
Q92542
Q8WW43
PDB IDs
2N7Q
2N7R
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
6LQG
6LR4
7C9I
7D8X
7Y5T
7Y5X
7Y5Z
8IM7
8K8E
8KCO
8KCP
8KCS
8KCT
8KCU
8OQY
8OQZ
8X52
8X53
8X54
8OQY
8OQZ
Enriched GO Terms of Interacting Partners
?
Gamma-secretase Complex
Amyloid-beta Formation
Amyloid Precursor Protein Catabolic Process
Amyloid-beta Metabolic Process
Amyloid Precursor Protein Metabolic Process
Notch Receptor Processing
Membrane Protein Proteolysis
Membrane Protein Ectodomain Proteolysis
Notch Signaling Pathway
Protein Processing
Protein Maturation
Membrane Protein Intracellular Domain Proteolysis
Synaptic Membrane
Enzyme Binding
Positive Regulation Of Proteolysis
Endopeptidase Activator Activity
Modulation Of Chemical Synaptic Transmission
Golgi Apparatus
Protein Metabolic Process
Endoplasmic Reticulum
Early Endosome
Presynaptic Membrane
Synaptic Vesicle
Golgi Membrane
Astrocyte Activation Involved In Immune Response
Neuron Projection Organization
Plasma Membrane
Regulation Of Proteolysis
Positive Regulation Of Amyloid Fibril Formation
Growth Factor Receptor Binding
Cellular Response To Amyloid-beta
Negative Regulation Of Axonogenesis
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Response To Amyloid-beta
Cell Surface Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cytokine Production
Cellular Response To Manganese Ion
Positive Regulation Of Apoptotic Process
Regulation Of Neuron Apoptotic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Programmed Cell Death
Learning Or Memory
Negative Regulation Of Long-term Synaptic Potentiation
Regulation Of Transport
Neuron Projection Maintenance
Endoplasmic Reticulum Membrane
Endosome Membrane
Signal Transduction
Gamma-secretase Complex
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Notch Receptor Processing
Amyloid-beta Formation
Amyloid Precursor Protein Catabolic Process
Membrane Protein Ectodomain Proteolysis
Amyloid-beta Metabolic Process
Amyloid Precursor Protein Metabolic Process
Membrane Protein Proteolysis
Growth Factor Receptor Binding
Synaptic Membrane
Notch Signaling Pathway
Presynaptic Membrane
Synaptic Vesicle
Protein Processing
Cerebellum Development
Azurophil Granule Membrane
Protein Maturation
Early Endosome
Negative Regulation Of Core Promoter Binding
Amyloid Precursor Protein Biosynthetic Process
ATPase Binding
Endopeptidase Activity
Myelination
Axon Ensheathment
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Peptidase Activity
Cajal-Retzius Cell Differentiation
Neuron Apoptotic Process
Sarcolemma
Protein Catabolic Process At Postsynapse
Negative Regulation Of Transcription Regulatory Region DNA Binding
Short-term Synaptic Potentiation
Negative Regulation Of Transcription By RNA Polymerase III
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Synaptic Vesicle Targeting
Astrocyte Activation Involved In Immune Response
Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process
Sequestering Of Calcium Ion
Positive Regulation Of Amyloid Fibril Formation
Kinetochore
Golgi Membrane
Regulation Of Calcium Import Into The Mitochondrion
Cytoplasmic Vesicle Membrane
Glucose Import In Response To Insulin Stimulus
Epithelial Cell Proliferation
Schwann Cell Differentiation
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Regulation Of Synaptic Plasticity
Regulation Of L-glutamate Import Across Plasma Membrane
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