CSNK2A2 and FGF2

Number of citations of the paper that reports this interaction (PMID 7735329)
6

Data Source:
HPRD (in vivo, in vitro)

		CSNK2A2	FGF2
Gene Name		casein kinase 2, alpha prime polypeptide	fibroblast growth factor 2 (basic)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol PcG Protein Complex	Extracellular Region Extracellular Space Nucleus
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding	Fibroblast Growth Factor Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Chemoattractant Activity
	Biological Process	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Axon Guidance Wnt Signaling Pathway Mitotic Spindle Checkpoint	Activation Of MAPK Activity Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Chemotaxis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Negative Regulation Of Fibroblast Migration Positive Regulation Of Phospholipase C Activity Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Extracellular Matrix Organization Hyaluronan Catabolic Process Inositol Phosphate Biosynthetic Process Somatic Stem Cell Maintenance Fc-epsilon Receptor Signaling Pathway Wound Healing Positive Regulation Of Cell Fate Specification Positive Regulation Of MAP Kinase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Embryonic Morphogenesis Positive Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cell Death Chondroblast Differentiation Negative Regulation Of Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Sprouting Angiogenesis Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways		Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Syndecan interactions Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R Transcriptional regulation of pluripotent stem cells PI3K events in ERBB2 signaling FGFR1b ligand binding and activation Downstream signaling of activated FGFR FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Non-integrin membrane-ECM interactions FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs			Sucralfate Pentosan Polysulfate Sirolimus 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
Diseases
GWAS
Protein-Protein Interactions		92 interactors: ABCA1 ACACA ADH1A AQP4 ARR3 ARRB2 ASL ATF1 ATF2 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L HDAC1 HDAC2 HDAC6 HIST1H1C HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 JUN KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL P4HB PAK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3	29 interactors: API5 CASP1 CD44 CEP57 CRYAB CSNK2A1 CSNK2A2 CSNK2B CXCL13 FGFBP1 FGFR1 FGFR3 FGFR4 FGFRL1 GPC3 GPC4 HSPG2 NRP1 PF4 PRMT1 PTX3 RPL6 RPS19 RPS6KA3 SDC1 SDC2 SDC3 THBS1 VTN
Entrez ID		1459	2247
HPRD ID		00279	00622
Ensembl ID		ENSG00000070770	ENSG00000138685
Uniprot IDs		P19784	P09038
PDB IDs		3E3B 3OFM 3U87	1BAS 1BFB 1BFC 1BFF 1BFG 1BLA 1BLD 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 4FGF
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Abiotic Stimulus Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Stimulus Regulation Of Gene Expression Developmental Process Innate Immune Response Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune System Process Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus Immune Response-regulating Signaling Pathway Cellular Response To Stress Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Response To Organic Cyclic Compound Regulation Of Signaling Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process Gene Expression Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Immune Response Regulation Of Phosphorylation Cell Differentiation Negative Regulation Of Signal Transduction Anatomical Structure Development Nitrogen Compound Metabolic Process Multicellular Organismal Development Defense Response Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression	Response To External Stimulus Glycosaminoglycan Catabolic Process Anatomical Structure Morphogenesis Anatomical Structure Development Response To Stimulus Cellular Response To Stimulus Signal Transduction Chondroitin Sulfate Metabolic Process Regulation Of Proteolysis Negative Regulation Of Proteolysis Developmental Process Negative Regulation Of Protein Processing Signaling Phototransduction, Visible Light Retinoid Metabolic Process Cell Communication Locomotion Cellular Response To Growth Factor Stimulus Regulation Of Protein Processing Positive Regulation Of Signal Transduction Diterpenoid Metabolic Process Response To Growth Factor Detection Of Visible Light Regulation Of Cellular Component Organization Chemotaxis System Development Glycosaminoglycan Metabolic Process Multicellular Organismal Development Phototransduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Glycosaminoglycan Biosynthetic Process Regulation Of Cellular Process Proteoglycan Metabolic Process Detection Of Light Stimulus Response To Organic Substance Cell Differentiation Pathogenesis Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Isoprenoid Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Defense Response Regulation Of Peptidase Activity Protein Metabolic Process Negative Regulation Of Peptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis	accumulated altering bdnf believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
Tagcloud (Difference) ?		bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis	accumulated altering bdnf believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
Tagcloud (Intersection) ?