CSNK2A2 and TCOF1

Number of citations of the paper that reports this interaction (PubMedID 10982400)
37

Data Source:
HPRD (in vivo)

		CSNK2A2	TCOF1
Description		casein kinase 2 alpha 2	treacle ribosome biogenesis factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Cytosol Protein Kinase CK2 Complex PcG Protein Complex	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Double-strand Break Repair Apoptotic Process DNA Damage Response Spermatogenesis Wnt Signaling Pathway Cerebral Cortex Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Liver Regeneration Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Apoptotic Signaling Pathway	Skeletal System Development Regulation Of Translation Neural Crest Formation Neural Crest Cell Development Nucleolar Large RRNA Transcription By RNA Polymerase I
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib
Diseases			Treacher Collins syndrome
GWAS		Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		104 interacting genes: ABCA1 ACACA ADH1A AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CEBPA CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GRIN2A GRIN2B GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3	11 interacting genes: CRK CSNK2A1 CSNK2A2 NOP56 PCNA PKNOX1 SPOP SRPK2 TM9SF1 UBC UBTF
Entrez ID		1459	6949
HPRD ID		00279	06026
Ensembl ID		ENSG00000070770	ENSG00000070814
Uniprot IDs		P19784	B4DRA2 E7ETY2 Q13428
PDB IDs		3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU 7A1B 7A1Z 7A22 7A2H 7AT9 7ATV 7XYH 8Q77 8Q9S 8QBU 8QCD 8QCG 8QF1
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Enzyme Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Alcohol Regulation Of Signal Transduction Regulation Of Metabolic Process Macromolecule Metabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Response To Stress Response To Alkaloid Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of RNA Metabolic Process	Protein Kinase CK2 Complex Nucleic Acid Metabolic Process PcG Protein Complex Liver Regeneration Nucleus Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Helper T Cell Diapedesis Cerebral Cortex Development Protein Phosphorylated Amino Acid Binding Ubiquitin Protein Ligase Binding Receptor Tyrosine Kinase Binding Scaffold Protein Binding Response To Cholecystokinin Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Nucleoplasm Negative Regulation Of Proteasomal Protein Catabolic Process RNA Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Chromosome Separation Animal Organ Regeneration PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Cerebellar Neuron Development Response To Hydrogen Peroxide Protein Serine/threonine Kinase Activity Symbiont-mediated Disruption Of Host Cell PML Body Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Liver Development Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Nuclear Speck Organization Regulation Of Glucose Mediated Signaling Pathway Negative Regulation Of Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Chromosome Segregation Positive Regulation Of Aggrephagy Regeneration Chromatin Binding RNA Polymerase I General Transcription Initiation Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity
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