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KLHL12 and KLHL2
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(two hybrid)
KLHL12
KLHL2
Gene Name
kelch-like family member 12
kelch-like family member 2
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytosol
ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Ruffle
Cytoplasm
Cytosol
Actin Cytoskeleton
Lamellipodium
Cul3-RING Ubiquitin Ligase Complex
Molecular Function
Protein Binding
Actin Binding
Protein Binding
Biological Process
Protein Monoubiquitination
ER To Golgi Vesicle-mediated Transport
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
Protein Ubiquitination
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
39 interactors:
ARAF
ATXN1
BAG6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CUL3
DGCR6
DRD4
DVL3
FGD2
FLNA
GLYCTK
INMT
KLHL2
KLHL3
LNX1
MED28
MPP1
MRPL10
NDC80
PDGFRB
PEF1
PRR13
RIT1
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TTBK2
UBE2I
VEGFB
VTA1
WDYHV1
ZBP1
15 interactors:
ACTC1
BCAM
CCDC43
CLK2
CUL3
KLHL12
SDCBP
TMA16
TNPO2
TXNDC12
UBE2C
UBE2D1
WNK1
WNK4
ZNF114
Entrez ID
59349
11275
HPRD ID
13925
09311
Ensembl ID
ENSG00000117153
ENSG00000109466
Uniprot IDs
Q53G59
O95198
PDB IDs
2VPJ
2XN4
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Coronary Vasculature Development
Actin Cytoskeleton Organization
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Chromosome Segregation
Actin Filament-based Process
Positive Regulation Of Catalytic Activity
Anatomical Structure Development
Cellular Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Modification-dependent Protein Catabolic Process
Cell Projection Assembly
Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Division
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Chemotaxis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Pancreatic Juice Secretion
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Chromosome Segregation
Negative Regulation Of Transferase Activity
Regulation Of Mitotic Nuclear Division
COPII Vesicle Coating
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
COPII-coated Vesicle Budding
Positive Regulation Of Cellular Protein Catabolic Process
Protein Polyubiquitination
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Vesicle Targeting, To, From Or Within Golgi
Regulation Of Proteasomal Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Regulation Of Chromosome Organization
Spindle Assembly Checkpoint
Protein K48-linked Ubiquitination
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Catabolic Process
Protein Ubiquitination
Mitotic Spindle Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitotic Nuclear Division
Protein Monoubiquitination
Localization Within Membrane
Negative Regulation Of Chromosome Segregation
Vesicle Targeting
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Kinase Activity
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Spindle Checkpoint
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Cell Division
Proteasomal Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Positive Regulation Of Proteolysis
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Catalytic Activity
Cellular Protein Modification Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
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