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KLHL12 and MRPL10
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
KLHL12
MRPL10
Gene Name
kelch-like family member 12
mitochondrial ribosomal protein L10
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytosol
ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Nucleoplasm
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Large Ribosomal Subunit
Ribonucleoprotein Complex
Molecular Function
Protein Binding
Structural Constituent Of Ribosome
Poly(A) RNA Binding
Biological Process
Protein Monoubiquitination
ER To Golgi Vesicle-mediated Transport
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
Translation
Organelle Organization
Mitochondrial Translation
Ribosome Biogenesis
Mitochondrial Translational Initiation
Mitochondrial Translational Elongation
Mitochondrial Translational Termination
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Mitochondrial translation
Organelle biogenesis and maintenance
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Drugs
Diseases
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Protein-Protein Interactions
39 interactors:
ARAF
ATXN1
BAG6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CUL3
DGCR6
DRD4
DVL3
FGD2
FLNA
GLYCTK
INMT
KLHL2
KLHL3
LNX1
MED28
MPP1
MRPL10
NDC80
PDGFRB
PEF1
PRR13
RIT1
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TTBK2
UBE2I
VEGFB
VTA1
WDYHV1
ZBP1
7 interactors:
APP
FAM9B
KLHL12
PNMA1
REL
TCF4
USP22
Entrez ID
59349
124995
HPRD ID
13925
14738
Ensembl ID
ENSG00000117153
ENSG00000159111
Uniprot IDs
Q53G59
Q7Z7H8
PDB IDs
2VPJ
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Coronary Vasculature Development
Actin Cytoskeleton Organization
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Chromosome Segregation
Actin Filament-based Process
Positive Regulation Of Catalytic Activity
Anatomical Structure Development
Cellular Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Modification-dependent Protein Catabolic Process
Cell Projection Assembly
Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Division
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Chemotaxis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Mitotic Cell Cycle
Synaptic Growth At Neuromuscular Junction
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Catenin Import Into Nucleus
Regulation Of Protein Binding
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Metabolic Process
Maintenance Of DNA Repeat Elements
Negative Regulation Of Wnt Signaling Pathway
Regulation Of Cell Cycle
Vesicle Localization
Collateral Sprouting
Axon Midline Choice Point Recognition
Regulation Of Canonical Wnt Signaling Pathway
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Embryonic Hindgut Morphogenesis
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Axon Choice Point Recognition
Embryonic Genitalia Morphogenesis
Positive Regulation Of Cellular Metabolic Process
Regulation Of Binding
Myoblast Fate Commitment
Wnt Signaling Pathway
Positive Regulation Of Cell Cycle
Regulation Of Developmental Growth
Neuron Remodeling
Secretory Granule Localization
Regulation Of Signal Transduction
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Hindgut Morphogenesis
Immune Response
Insulin Metabolic Process
Positive Regulation Of Interleukin-12 Biosynthetic Process
Defense Response
Hindgut Development
Regulation Of Signaling
Positive Regulation Of Protein Export From Nucleus
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of Triglyceride Biosynthetic Process
RNA Metabolic Process
Positive Regulation Of Glycoprotein Metabolic Process
Regulation Of Interleukin-12 Biosynthetic Process
Tagcloud
?
15k
cdnas
characters
clustering
developmentally
dncic2
dosage
ds
eef1g
eif3sf
extra
hchr21
hierarchical
manifested
mrps18a
neurogenesis
neuron
neuropathological
outgrowth
patterned
peg3
phenotypic
retardation
sf3a60
snapc3
srprb
syngr2
tt2f
ubce8
Tagcloud (Difference)
?
15k
cdnas
characters
clustering
developmentally
dncic2
dosage
ds
eef1g
eif3sf
extra
hchr21
hierarchical
manifested
mrps18a
neurogenesis
neuron
neuropathological
outgrowth
patterned
peg3
phenotypic
retardation
sf3a60
snapc3
srprb
syngr2
tt2f
ubce8
Tagcloud (Intersection)
?