KLHL12 and RGL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL12	RGL3
Description		kelch like family member 12	ral guanine nucleotide dissociation stimulator like 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Cytosol Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways		Degradation of DVL	RAF/MAP kinase cascade
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618447 27618448 27841878) Hypertension ( 27618447 27618448 32709000 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878 27618447) Systolic blood pressure ( 28135244 27841878 30578418 27618448 27618447)
Interacting Genes		58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4	6 interacting genes: FAM200A KLHL12 NRAS RIT1 RIT2 RRAS2
Entrez ID		59349	57139
HPRD ID		13925	18844
Ensembl ID		ENSG00000117153	ENSG00000205517
Uniprot IDs		Q53G59 Q9H7R2	Q3MIN7
PDB IDs		2VPJ 6TTK 6V7O 8OIO 8RBH
Enriched GO Terms of Interacting Partners?		Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion	Ras Protein Signal Transduction GDP Binding Small GTPase-mediated Signal Transduction G Protein Activity GTPase Activity GTP Binding Intracellular Signaling Cassette Hydrolase Activity Dendritic Tree Positive Regulation Of Schwann Cell Migration Schwann Cell Migration Nucleotide Binding Intracellular Signal Transduction Calmodulin Binding MAPK Cascade Neural Crest Formation Positive Regulation Of Glial Cell Migration Regulation Of Cdc42 Protein Signal Transduction Signal Transduction
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