KLHL12 and DRD4

Number of citations of the paper that reports this interaction (PMID 18303015)
17

Data Source:
HPRD (in vivo, two hybrid)

		KLHL12	DRD4
Gene Name		kelch-like family member 12	dopamine receptor D4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Vesicle Membrane Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine
	Molecular Function	Protein Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Protein Binding Drug Binding Potassium Channel Regulator Activity SH3 Domain Binding Dopamine Binding Identical Protein Binding
	Biological Process	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway	Activation Of MAPK Activity Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Short-term Memory Circadian Rhythm Adult Locomotory Behavior Olfactory Learning Photoperiodism Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Regulation Of Neurotransmitter Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Response To Steroid Hormone Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Regulation Of Calcium-mediated Signaling Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Penile Erection Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Remoxipride Pramipexole Promazine Lisuride Apomorphine Risperidone Propiomazine Dopamine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Iloperidone Rotigotine Asenapine
Diseases
GWAS
Protein-Protein Interactions		39 interactors: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CUL3 DGCR6 DRD4 DVL3 FGD2 FLNA GLYCTK INMT KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 NDC80 PDGFRB PEF1 PRR13 RIT1 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 WDYHV1 ZBP1	6 interactors: CLIC6 GABRA1 GRB2 KCNJ9 KLHL12 NCK1
Entrez ID		59349	1815
HPRD ID		13925	00541
Ensembl ID		ENSG00000117153	ENSG00000069696
Uniprot IDs		Q53G59	P21917
PDB IDs		2VPJ
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Coronary Vasculature Development Actin Cytoskeleton Organization Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Chromosome Segregation Actin Filament-based Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Cellular Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Modification-dependent Protein Catabolic Process Cell Projection Assembly Regulation Of MAP Kinase Activity Positive Regulation Of Cell Division Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division	Transport Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Actin Filament Polymerization Chloride Transmembrane Transport Positive Regulation Of Protein Polymerization Chloride Transport Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Cell-cell Signaling Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Signal Transduction Inorganic Anion Transport Phagocytosis Cellular Response To Histamine Synaptic Transmission, GABAergic Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of T Cell Activation Positive Regulation Of Cell Activation Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Cellular Component Biogenesis Response To Histamine Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytoplasmic Translation Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Ion Transmembrane Transport Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation
Tagcloud ?			adhd cleft clefting collect conceptual dat1 disabilities disruptive dopamine drd2 familial genotyped heritability hyperactivity impulse inattention inattentive neurobehavioral ofc orofacial overlap pilot polymorphisms proposing restlessness saliva stressors taq1a1 warranted
Tagcloud (Difference) ?			adhd cleft clefting collect conceptual dat1 disabilities disruptive dopamine drd2 familial genotyped heritability hyperactivity impulse inattention inattentive neurobehavioral ofc orofacial overlap pilot polymorphisms proposing restlessness saliva stressors taq1a1 warranted
Tagcloud (Intersection) ?