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KLHL12 and CARD10
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
KLHL12
CARD10
Gene Name
kelch-like family member 12
caspase recruitment domain family, member 10
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytosol
ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Cytoplasm
CBM Complex
Molecular Function
Protein Binding
Protein Binding
Receptor Signaling Complex Scaffold Activity
Biological Process
Protein Monoubiquitination
ER To Golgi Vesicle-mediated Transport
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
Protein Complex Assembly
Activation Of NF-kappaB-inducing Kinase Activity
Regulation Of Apoptotic Process
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Optic disc parameters (
21307088
)
Protein-Protein Interactions
39 interactors:
ARAF
ATXN1
BAG6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CUL3
DGCR6
DRD4
DVL3
FGD2
FLNA
GLYCTK
INMT
KLHL2
KLHL3
LNX1
MED28
MPP1
MRPL10
NDC80
PDGFRB
PEF1
PRR13
RIT1
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TTBK2
UBE2I
VEGFB
VTA1
WDYHV1
ZBP1
4 interactors:
ATXN7
BCL10
IKBKG
KLHL12
Entrez ID
59349
29775
HPRD ID
13925
06233
Ensembl ID
ENSG00000117153
ENSG00000100065
Uniprot IDs
Q53G59
Q8NC81
Q9BWT7
PDB IDs
2VPJ
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Coronary Vasculature Development
Actin Cytoskeleton Organization
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Chromosome Segregation
Actin Filament-based Process
Positive Regulation Of Catalytic Activity
Anatomical Structure Development
Cellular Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Modification-dependent Protein Catabolic Process
Cell Projection Assembly
Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Division
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Chemotaxis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Toll-like Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Activation Of Innate Immune Response
Regulation Of Signaling
Positive Regulation Of Mast Cell Cytokine Production
Lymphotoxin A Biosynthetic Process
Interleukin-6 Biosynthetic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Innate Immune Response
Negative Regulation Of Signal Transduction
Establishment Of Vesicle Localization
Vesicle Localization
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Signaling
Fc-epsilon Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Mature B Cell Apoptotic Process
Regulation Of Innate Immune Response
Regulation Of Phosphorylation
Positive Regulation Of Transcription, DNA-templated
Fc Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Interleukin-6 Production
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Establishment Of Organelle Localization
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Interleukin-8 Biosynthetic Process
Positive Regulation Of Cytokine Production
B Cell Apoptotic Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of B Cell Apoptotic Process
Organelle Localization
Regulation Of Interleukin-8 Biosynthetic Process
Immune Response-regulating Signaling Pathway
T Cell Apoptotic Process
Regulation Of Cytokine Production
Regulation Of B Cell Apoptotic Process
Histone Deubiquitination
COPII Vesicle Coating
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
COPII-coated Vesicle Budding
Tagcloud
?
100nm
24h
26s
4t1
avenues
bortezomib
controversial
dffb
entirely
folding
grp78
ingenuity
ipa
label
lc
modulated
myeloma
noxa
nucleic
proteasomal
proteasome
proteolytic
psmd14
puma
sequestosome
tceb2
top
traf3
trp53bp2
Tagcloud (Difference)
?
100nm
24h
26s
4t1
avenues
bortezomib
controversial
dffb
entirely
folding
grp78
ingenuity
ipa
label
lc
modulated
myeloma
noxa
nucleic
proteasomal
proteasome
proteolytic
psmd14
puma
sequestosome
tceb2
top
traf3
trp53bp2
Tagcloud (Intersection)
?