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KLHL2 and WNK4
Number of citations of the paper that reports this interaction (PMID
23838290
)
3
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study, unspecified method, x-ray crystallography)
KLHL2
WNK4
Gene Name
kelch-like family member 2
WNK lysine deficient protein kinase 4
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Actin Cytoskeleton
Lamellipodium
Cul3-RING Ubiquitin Ligase Complex
Cytoplasm
Tight Junction
Molecular Function
Actin Binding
Protein Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Chloride Channel Inhibitor Activity
Biological Process
Protein Ubiquitination
Protein Phosphorylation
Ion Transport
Chloride Transport
Protein Localization
Intracellular Signal Transduction
Regulation Of Cellular Process
Ion Homeostasis
Renal Sodium Ion Absorption
Distal Tubule Morphogenesis
Negative Regulation Of Pancreatic Juice Secretion
Pathways
Ion channel transport
Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions
15 interactors:
ACTC1
BCAM
CCDC43
CLK2
CUL3
KLHL12
SDCBP
TMA16
TNPO2
TXNDC12
UBE2C
UBE2D1
WNK1
WNK4
ZNF114
11 interactors:
AKT1
BCL6
CLDN1
CLDN2
CLDN3
CLDN4
KLHL2
KLHL3
NEDD4L
SLC12A3
STK39
Entrez ID
11275
65266
HPRD ID
09311
03505
Ensembl ID
ENSG00000109466
ENSG00000126562
Uniprot IDs
O95198
B0LPI0
Q96J92
PDB IDs
2XN4
2V3S
Enriched GO Terms of Interacting Partners
?
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Pancreatic Juice Secretion
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Chromosome Segregation
Negative Regulation Of Transferase Activity
Regulation Of Mitotic Nuclear Division
COPII Vesicle Coating
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
COPII-coated Vesicle Budding
Positive Regulation Of Cellular Protein Catabolic Process
Protein Polyubiquitination
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Vesicle Targeting, To, From Or Within Golgi
Regulation Of Proteasomal Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Regulation Of Chromosome Organization
Spindle Assembly Checkpoint
Protein K48-linked Ubiquitination
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Catabolic Process
Protein Ubiquitination
Mitotic Spindle Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitotic Nuclear Division
Protein Monoubiquitination
Localization Within Membrane
Negative Regulation Of Chromosome Segregation
Vesicle Targeting
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Kinase Activity
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Spindle Checkpoint
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Cell Division
Proteasomal Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Positive Regulation Of Proteolysis
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Catalytic Activity
Cellular Protein Modification Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Negative Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transmembrane Transport
Water Homeostasis
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Cell-cell Adhesion
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Ion Transport
Homeostatic Process
Negative Regulation Of Potassium Ion Transmembrane Transport
Chemical Homeostasis
Establishment Of Skin Barrier
Regulation Of Water Loss Via Skin
Negative Regulation Of Potassium Ion Transport
Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Ion Transport
Protein Import Into Nucleus, Translocation
Protein Ubiquitination
Positive Regulation Of Sodium Ion Transport
Protein Modification By Small Protein Conjugation
Regulation Of Potassium Ion Transmembrane Transport
Protein K48-linked Ubiquitination
Negative Regulation Of Transporter Activity
Sodium Ion Transport
Multicellular Organismal Water Homeostasis
Regulation Of Potassium Ion Transport
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Sodium Ion Transport
Glycogen Cell Differentiation Involved In Embryonic Placenta Development
Negative Regulation Of Transport
Response To Osmotic Stress
Regulation Of Ion Transmembrane Transport
Positive Regulation Of Caveolin-mediated Endocytosis
Response To Abiotic Stimulus
Peptidyl-serine Phosphorylation
Negative Regulation Of Mast Cell Cytokine Production
Distal Tubule Morphogenesis
Negative Regulation Of Rubidium Ion Transport
Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity
Negative Regulation Of Isotype Switching To IgE Isotypes
Protein Import Into Nucleus
Nuclear Import
Cell Adhesion
Negative Regulation Of T-helper 2 Cell Differentiation
Renal Sodium Ion Absorption
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Negative Regulation Of Fatty Acid Beta-oxidation
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Regulation Of Body Fluid Levels
Tagcloud
?
aii
cotransporter
cul3
cullin
depletion
directing
hyperkalemia
hypertension
impair
inverse
kelch
klhl3
ligase
maximize
maximized
missense
nacl
obligatory
obscure
phenocopy
physiologic
posited
prevents
reabsorption
s433
salt
volume
wnk1
wnks
Tagcloud (Difference)
?
aii
cotransporter
cul3
cullin
depletion
directing
hyperkalemia
hypertension
impair
inverse
kelch
klhl3
ligase
maximize
maximized
missense
nacl
obligatory
obscure
phenocopy
physiologic
posited
prevents
reabsorption
s433
salt
volume
wnk1
wnks
Tagcloud (Intersection)
?