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KLHL2
Gene Name
kelch-like family member 2
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Actin Cytoskeleton
Lamellipodium
Cul3-RING Ubiquitin Ligase Complex
Molecular Function
Actin Binding
Protein Binding
Biological Process
Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions
15 interactors:
ACTC1
BCAM
CCDC43
CLK2
CUL3
KLHL12
SDCBP
TMA16
TNPO2
TXNDC12
UBE2C
UBE2D1
WNK1
WNK4
ZNF114
Entrez ID
11275
HPRD ID
09311
Ensembl ID
ENSG00000109466
Uniprot IDs
O95198
PDB IDs
2XN4
Enriched GO Terms of Interacting Partners
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Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Pancreatic Juice Secretion
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Chromosome Segregation
Negative Regulation Of Transferase Activity
Regulation Of Mitotic Nuclear Division
COPII Vesicle Coating
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
COPII-coated Vesicle Budding
Positive Regulation Of Cellular Protein Catabolic Process
Protein Polyubiquitination
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Vesicle Targeting, To, From Or Within Golgi
Regulation Of Proteasomal Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Regulation Of Chromosome Organization
Spindle Assembly Checkpoint
Protein K48-linked Ubiquitination
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Catabolic Process
Protein Ubiquitination
Mitotic Spindle Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitotic Nuclear Division
Protein Monoubiquitination
Localization Within Membrane
Negative Regulation Of Chromosome Segregation
Vesicle Targeting
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Kinase Activity
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Spindle Checkpoint
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Cell Division
Proteasomal Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Positive Regulation Of Proteolysis
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Catalytic Activity
Cellular Protein Modification Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
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