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KLHL12 and ZBP1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
KLHL12
ZBP1
Gene Name
kelch-like family member 12
Z-DNA binding protein 1
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytosol
ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
Protein Binding
DNA Binding
Left-handed Z-DNA Binding
RNA Binding
Double-stranded RNA Adenosine Deaminase Activity
Protein Binding
Biological Process
Protein Monoubiquitination
ER To Golgi Vesicle-mediated Transport
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
Biological_process
Metabolic Process
Positive Regulation Of Type I Interferon Production
Innate Immune Response
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Regulation of innate immune responses to cytosolic DNA
ZBP1(DAI) mediated induction of type I IFNs
IRF3 mediated activation of type 1 IFN
Cytosolic sensors of pathogen-associated DNA
STING mediated induction of host immune responses
IRF3-mediated induction of type I IFN
RIP-mediated NFkB activation via ZBP1
Innate Immune System
Drugs
Diseases
GWAS
Hippocampal atrophy (
19668339
)
Response to fenofibrate (adiponectin levels) (
23149075
)
Protein-Protein Interactions
39 interactors:
ARAF
ATXN1
BAG6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CUL3
DGCR6
DRD4
DVL3
FGD2
FLNA
GLYCTK
INMT
KLHL2
KLHL3
LNX1
MED28
MPP1
MRPL10
NDC80
PDGFRB
PEF1
PRR13
RIT1
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TTBK2
UBE2I
VEGFB
VTA1
WDYHV1
ZBP1
8 interactors:
CTBP1
CTBP2
KLHL12
PALD1
PLXDC2
SIAH1
TRAF3
TRIP6
Entrez ID
59349
81030
HPRD ID
13925
09484
Ensembl ID
ENSG00000117153
ENSG00000124256
Uniprot IDs
Q53G59
Q9H171
PDB IDs
2VPJ
2L4M
2LNB
3EYI
4KA4
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Coronary Vasculature Development
Actin Cytoskeleton Organization
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Chromosome Segregation
Actin Filament-based Process
Positive Regulation Of Catalytic Activity
Anatomical Structure Development
Cellular Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Modification-dependent Protein Catabolic Process
Cell Projection Assembly
Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Division
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Chemotaxis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
White Fat Cell Differentiation
Viral Genome Replication
Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Fat Cell Differentiation
Viral Life Cycle
Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Release Of Cytoplasmic Sequestered NF-kappaB
Positive Regulation Of Chromatin Binding
Tagcloud
?
concerted
contain
continuum
cpeb
ddx6
dendritic
dormant
engaged
fmrp
foci
fus
granules
hud
masked
messengers
mrnas
polysomes
pumilio
rbps
repressed
smaug
stalled
staufen
synapse
thousands
tls
transcriptome
translational
trapped
Tagcloud (Difference)
?
concerted
contain
continuum
cpeb
ddx6
dendritic
dormant
engaged
fmrp
foci
fus
granules
hud
masked
messengers
mrnas
polysomes
pumilio
rbps
repressed
smaug
stalled
staufen
synapse
thousands
tls
transcriptome
translational
trapped
Tagcloud (Intersection)
?