KLHL2 and CWC22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL2	CWC22
Description		kelch like family member 2	CWC22 spliceosome associated protein
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Speck U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Binding Protein Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Adult body size ( 32376654) Body mass index ( 28892062) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Schizophrenia ( 30285260)
Interacting Genes		29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	7 interacting genes: CFTR EIF4A3 EXOSC8 KLHL2 PDAP1 PTPN21 RNF10
Entrez ID		11275	57703
HPRD ID		09311	17220
Ensembl ID		ENSG00000109466	ENSG00000163510
Uniprot IDs		B4DFZ5 E9PEX9 O95198	Q9HCG8
PDB IDs		2XN4 4CHB	4C9B 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF7 6ICZ 6QDV 6YVH 6ZYM 7A5P 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 9FMD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis	Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Macromolecule Catabolic Process Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Nervous System Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Positive Regulation Of Enamel Mineralization Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Translational Elongation RNA Catabolic Process Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation RRNA Processing Negative Regulation Of Schwann Cell Proliferation U4 SnRNA 3'-end Processing Amelogenesis Cellular Response To Brain-derived Neurotrophic Factor Stimulus Ribosome-associated Ubiquitin-dependent Protein Catabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Translational Elongation Negative Regulation Of Excitatory Postsynaptic Potential Catabolic Process RRNA Metabolic Process TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance U2-type Catalytic Step 1 Spliceosome
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