KLHL12 and KLHL3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KLHL12	KLHL3
Description		kelch like family member 12	kelch like family member 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Gene Expression Macroautophagy Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Monoatomic Ion Homeostasis Potassium Ion Homeostasis Renal Absorption Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways		Degradation of DVL	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4	16 interacting genes: AKT1 CFAP206 GNAI1 GNAO1 KLHL12 MORF4L2 OPRD1 PPP3CA PRKACA RBX1 SYNCRIP SYT2 TNPO2 UBE2D3 WNK3 WNK4
Entrez ID		59349	26249
HPRD ID		13925	09011
Ensembl ID		ENSG00000117153	ENSG00000146021
Uniprot IDs		Q53G59 Q9H7R2	Q9UH77
PDB IDs		2VPJ 6TTK 6V7O 8OIO 8RBH	4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?		Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion	Renal Sodium Ion Transport Renal Sodium Ion Absorption Renal Absorption Renal System Process Regulation Of Metal Ion Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Secretion Negative Regulation Of Protein Localization Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Proteasomal Protein Catabolic Process Regulation Of Transport Positive Regulation Of Steroid Biosynthetic Process Adenylate Cyclase Regulator Activity Positive Regulation Of Steroid Metabolic Process Negative Regulation Of Pancreatic Juice Secretion Ubiquitin-dependent Protein Catabolic Process Regulation Of System Process Modification-dependent Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization Regulation Of Cholesterol Metabolic Process Protein Catabolic Process Negative Regulation Of Secretion Protein Monoubiquitination Sodium Ion Transport Proteolysis Involved In Protein Catabolic Process TORC1 Signaling Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Negative Regulation Of TORC1 Signaling Regulation Of Sodium Ion Transport Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Calcium Ion Transport Regulation Of Steroid Biosynthetic Process Protein Modification Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway TOR Signaling Negative Regulation Of TOR Signaling Nuclear Transport Nucleocytoplasmic Transport Vascular Endothelial Cell Response To Fluid Shear Stress Nucleotide Binding
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