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KLHL12 and ATXN1
Number of citations of the paper that reports this interaction (PMID
16713569
)
214
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
HPRD
(two hybrid)
KLHL12
ATXN1
Gene Name
kelch-like family member 12
ataxin 1
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytosol
ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
Nuclear RNA Export Factor Complex
Nuclear Inclusion Body
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
DNA Binding
Chromatin Binding
Protein Binding
Protein C-terminus Binding
Poly(U) RNA Binding
Poly(G) Binding
Identical Protein Binding
Protein Self-association
Biological Process
Protein Monoubiquitination
ER To Golgi Vesicle-mediated Transport
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Processing
Adult Locomotory Behavior
Visual Learning
Negative Regulation Of Phosphorylation
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Lung Alveolus Development
Nuclear Export
Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (
19451621
)
Gambling (
22780124
)
Major depressive disorder (
23377640
)
Protein-Protein Interactions
39 interactors:
ARAF
ATXN1
BAG6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CUL3
DGCR6
DRD4
DVL3
FGD2
FLNA
GLYCTK
INMT
KLHL2
KLHL3
LNX1
MED28
MPP1
MRPL10
NDC80
PDGFRB
PEF1
PRR13
RIT1
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TTBK2
UBE2I
VEGFB
VTA1
WDYHV1
ZBP1
252 interactors:
ACACA
ACOT7
ADCY6
ADD3
AHDC1
AKT1
ANKHD1
ANP32A
APBB1
ARHGAP32
ARID5A
ASNS
ATF5
ATP1A3
ATP6V0D1
ATXN1L
ATXN2
ATXN2L
BAALC
BASP1
BATF2
BEND2
BTG3
C1orf94
C2orf27B
CAMK2B
CCDC136
CCNK
CDIP1
CDK6
CFL1
CHRNA7
CIC
CIRBP
CLASRP
CLCN2
CLEC4F
COIL
CPSF7
CREM
CRIP2
CRK
CRY2
CST3
DAZAP2
DCTN3
DHRSX
DHX37
DIXDC1
DMPK
DNAJA3
DOCK5
DZIP3
EFEMP2
EHMT1
EIF1AY
EIF1B
EIF3F
EIF4ENIF1
ELP5
ENTPD6
ESRP1
ESRRA
ETV4
FAM193B
FAM21C
FAM46A
FAM46B
FAR1
FAT4
FDPS
FHL2
FOSL1
FUBP3
FYN
GAPDH
GATAD1
GCA
GCFC2
GGA2
GMEB2
GPATCH8
GSPT1
HEY2
HEYL
HIST1H3A
HIVEP1
HNRNPLL
HOTAIR
HPCAL1
HSFX1
HSPA1A
HYPM
IGF2R
IL34
ILVBL
IMMT
IPO8
IST1
ITGB4
KAT5
KAT6A
KCNAB2
KCTD15
KIAA1549L
KIAA2026
KIF22
KLF11
KLHL12
KLHL8
KMT2B
LASP1
LDB1
LITAF
LOC401442
LOXL1
LPAR2
LRSAM1
MAGEB18
MAGEB2
MAGEB6
MATN2
MBP
MED15
METTL17
MLST8
MSMO1
MSX2
MTERF4
MYO18A
NARS
NCAM1
NCOR1
NCOR2
NLK
NPHP3
NR4A1
NUDT21
NUMBL
NUTM2B
OAZ1
OPCML
OTX2
PEPD
PHPT1
PIAS1
PIM2
PLEKHB1
PML
POM121
PPAT
PPP6R2
PQBP1
PRDM1
PRR20A
PRRC2A
PRRC2B
PSMC3
PSPH
PTGDS
PUM1
QKI
QRICH1
R3HDM1
R3HDM2
RAD54L2
RAI2
RAPGEF1
RAPGEF4
RBFOX1
RBFOX2
RBM26
RBPMS
RCN1
REL
RHOXF2
RNF31
RNF4
SAR1A
SEMA4G
SETD2
SF1
SGMS1
SIX5
SLC25A51
SLC4A2
SLC51A
SLC6A13
SMARCC2
SPEN
SREBF1
SREBF2
ST6GALNAC6
STAC2
STAM2
SUGP2
SUMO1
SUMO2
SUPT20H
SV2A
SYBU
TBC1D5
TBX15
TCAP
TCEANC
TCTA
TDP2
TMX2
TOLLIP
TOMM20
TOX4
TP53I11
TRAF2
TRIM32
TRIM38
TRIP6
TSC1
TTC19
U2AF2
UBAP2L
UBE2E3
UBE2I
UBQLN4
UHRF1BP1L
UHRF2
UNK
USP54
USP7
VCP
VSNL1
VSTM2L
WBSCR16
WNK1
WNK2
YWHAE
YWHAZ
YY1AP1
ZBTB32
ZC3H10
ZC3H7B
ZCCHC13
ZHX1
ZHX2
ZHX3
ZNF276
ZNF488
ZNF609
ZNF804A
ZSCAN1
ZSWIM8
ZXDC
ZYX
Entrez ID
59349
6310
HPRD ID
13925
03333
Ensembl ID
ENSG00000117153
ENSG00000124788
Uniprot IDs
Q53G59
P54253
Q96FF1
PDB IDs
2VPJ
1OA8
4APT
4AQP
4J2J
4J2L
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Coronary Vasculature Development
Actin Cytoskeleton Organization
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Chromosome Segregation
Actin Filament-based Process
Positive Regulation Of Catalytic Activity
Anatomical Structure Development
Cellular Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Modification-dependent Protein Catabolic Process
Cell Projection Assembly
Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Division
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Chemotaxis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Gene Expression
RNA Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Transcription, DNA-templated
Negative Regulation Of RNA Biosynthetic Process
RNA Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Gene Expression
Regulation Of Gene Expression
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Response To Organic Substance
Multicellular Organismal Development
Positive Regulation Of Metabolic Process
Developmental Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Differentiation
System Development
Anatomical Structure Development
Cell Differentiation
Organ Development
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Gene Expression
Cellular Response To Organic Substance
Cellular Process
Response To Stress
Positive Regulation Of Cellular Protein Metabolic Process
Generation Of Neurons
Response To Stimulus
Tagcloud
?
akap6
atf7
bmpr2
categorize
deltan
eef1a1
grip2
gtf2f1
interactors
jbd
jbds
jnk1alpha1
jnk3
jnk3alpha1
jnks
kcne4
myo9b
nnat
pias1
ptgds
ptpn2
rabgap1
rusc2
shank1
sumo1
sypl1
tkt
topbp1
znf668
Tagcloud (Difference)
?
akap6
atf7
bmpr2
categorize
deltan
eef1a1
grip2
gtf2f1
interactors
jbd
jbds
jnk1alpha1
jnk3
jnk3alpha1
jnks
kcne4
myo9b
nnat
pias1
ptgds
ptpn2
rabgap1
rusc2
shank1
sumo1
sypl1
tkt
topbp1
znf668
Tagcloud (Intersection)
?