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KLHL12 and PDGFRB
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
KLHL12
PDGFRB
Gene Name
kelch-like family member 12
platelet-derived growth factor receptor, beta polypeptide
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytosol
ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Integral Component Of Membrane
Cytoplasmic Membrane-bounded Vesicle
Apical Plasma Membrane
Intrinsic Component Of Plasma Membrane
Lysosomal Lumen
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor-activated Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Phosphatidylinositol 3-kinase Binding
Platelet-derived Growth Factor Binding
Biological Process
Protein Monoubiquitination
ER To Golgi Vesicle-mediated Transport
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
In Utero Embryonic Development
Tissue Homeostasis
Glycosaminoglycan Biosynthetic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Adrenal Gland Development
Positive Regulation Of Cell Migration
Response To Estradiol
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Retinoic Acid
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Response To Fluid Shear Stress
Cell Migration Involved In Vasculogenesis
Metanephric Mesenchymal Cell Migration
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Wound Healing
Response To Hydrogen Peroxide
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Mitotic Nuclear Division
Phosphatidylinositol Metabolic Process
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Smooth Muscle Cell Proliferation
Skeletal System Morphogenesis
Smooth Muscle Tissue Development
Inner Ear Development
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Chemotaxis
Cardiac Myofibril Assembly
Response To Hyperoxia
Cell Chemotaxis
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Mesenchyme Development
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Metanephric Comma-shaped Body Morphogenesis
Metanephric S-shaped Body Morphogenesis
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
PIP3 activates AKT signaling
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Innate Immune System
Signaling by PDGF
Signalling by NGF
DAP12 interactions
GAB1 signalosome
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
Pazopanib
Regorafenib
Diseases
GWAS
Protein-Protein Interactions
39 interactors:
ARAF
ATXN1
BAG6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CUL3
DGCR6
DRD4
DVL3
FGD2
FLNA
GLYCTK
INMT
KLHL2
KLHL3
LNX1
MED28
MPP1
MRPL10
NDC80
PDGFRB
PEF1
PRR13
RIT1
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TTBK2
UBE2I
VEGFB
VTA1
WDYHV1
ZBP1
59 interactors:
ARAF
BAG1
CAV1
CAV3
CBL
COPA
COPB1
CRK
EGFR
EIF2AK2
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KRTAP4-12
NCK1
NCK2
NEDD4
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PRDX2
PTK2
PTPN1
PTPN11
PTPN2
PTPRJ
RAF1
RASA1
S1PR1
SHC1
SLC9A3R1
SNX1
SNX2
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TRIP6
TYK2
VAV1
YES1
Entrez ID
59349
5159
HPRD ID
13925
01423
Ensembl ID
ENSG00000117153
ENSG00000113721
Uniprot IDs
Q53G59
P09619
Q59F04
PDB IDs
2VPJ
1GQ5
1H9O
1LWP
2L6W
2PLD
2PLE
3MJG
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Coronary Vasculature Development
Actin Cytoskeleton Organization
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Chromosome Segregation
Actin Filament-based Process
Positive Regulation Of Catalytic Activity
Anatomical Structure Development
Cellular Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Modification-dependent Protein Catabolic Process
Cell Projection Assembly
Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Division
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Chemotaxis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Organonitrogen Compound
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Regulation Of Signal Transduction
Regulation Of Signaling
Epidermal Growth Factor Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Phosphorylation
Regulation Of Body Fluid Levels
Regulation Of Immune System Process
Response To Peptide Hormone
Signal Transduction
Regulation Of Immune Response
Response To Peptide
Blood Coagulation
Hemostasis
Regulation Of Phosphorus Metabolic Process
Signaling
Cell Communication
Innate Immune Response
Response To Organonitrogen Compound
Cellular Response To Hormone Stimulus
Regulation Of Kinase Activity
Wound Healing
Immune System Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cellular Response To Organic Substance
Fc Receptor Signaling Pathway
Cellular Response To Stimulus
Regulation Of Intracellular Signal Transduction
Locomotion
Positive Regulation Of Signal Transduction
Response To Wounding
Cell Migration
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Hormone
Neurotrophin TRK Receptor Signaling Pathway
Defense Response
Neurotrophin Signaling Pathway
Leukocyte Migration
Cell Motility
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response
Regulation Of Protein Phosphorylation
Response To Organic Substance
Tagcloud
?
14q32
5q31
5q33
apart
apl
aspirate
break
complication
cytogenetic
cytogenetics
exon
firstly
fusion
infrequent
kiaa1509
myeloid
neoplasm
neoplasms
partner
promyelocytic
q32
q33
rara
rarely
rearrangement
rt
trip11
undetectable
xy
Tagcloud (Difference)
?
14q32
5q31
5q33
apart
apl
aspirate
break
complication
cytogenetic
cytogenetics
exon
firstly
fusion
infrequent
kiaa1509
myeloid
neoplasm
neoplasms
partner
promyelocytic
q32
q33
rara
rarely
rearrangement
rt
trip11
undetectable
xy
Tagcloud (Intersection)
?