KLHL2 and ZNF114

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		KLHL2	ZNF114
Description		kelch like family member 2	zinc finger protein 114
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection	Nucleus Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Generic Transcription Pathway
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	10 interacting genes: CENATAC CLIP4 KIAA0753 KLHL2 KRTAP10-6 MAP7 MYO15B SUFU TPPP ZNF8
Entrez ID		11275	163071
HPRD ID		09311	14463
Ensembl ID		ENSG00000109466	ENSG00000178150
Uniprot IDs		B4DFZ5 E9PEX9 O95198	Q8NC26
PDB IDs		2XN4 4CHB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis	Cytoskeleton Microtubule-based Process Postsynaptic Golgi Apparatus Cytoplasmic Microtubule Organization Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Positive Regulation Of Response To Drug Microtubule Organizing Center
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