KLHL2 and TXNDC12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		KLHL2	TXNDC12
Description		kelch like family member 2	thioredoxin domain containing 12
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Protein-disulfide Reductase Activity Oxidoreductase Activity Protein-disulfide Reductase (glutathione) Activity
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	9 interacting genes: CAMLG DPF2 FKBP7 KLHL2 SGTA SGTB UBQLN1 UBQLN2 ZDHHC17
Entrez ID		11275	51060
HPRD ID		09311	11633
Ensembl ID		ENSG00000109466	ENSG00000117862
Uniprot IDs		B4DFZ5 E9PEX9 O95198	O95881
PDB IDs		2XN4 4CHB	1SEN 2K8V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis	TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Identical Protein Binding Protein Insertion Into ER Membrane Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Membrane Positive Regulation Of Proteolysis Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Protein Catabolic Process Response To Endoplasmic Reticulum Stress Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Myeloid Progenitor Cell Differentiation Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Store-operated Calcium Channel Activity Protein Insertion Into Membrane Protein Targeting To Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Autophagosome Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Internalization Autophagosome Assembly Autophagosome Organization Macromolecule Catabolic Process GET Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Protein Catabolic Process Localization Within Membrane Regulation Of Myeloid Progenitor Cell Differentiation Histone H3K14ac Reader Activity BAT3 Complex Binding Proteolysis Negative Regulation Of Clathrin-dependent Endocytosis
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