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KLHL2 and WNK1
Number of citations of the paper that reports this interaction (PMID
23838290
)
3
Data Source:
BioGRID
(affinity chromatography technology, unspecified method)
KLHL2
WNK1
Gene Name
kelch-like family member 2
WNK lysine deficient protein kinase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Actin Cytoskeleton
Lamellipodium
Cul3-RING Ubiquitin Ligase Complex
Cytoplasm
Molecular Function
Actin Binding
Protein Binding
Protein Serine/threonine Kinase Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Chloride Channel Inhibitor Activity
Phosphatase Binding
Biological Process
Protein Ubiquitination
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Ion Transport
Negative Regulation Of Phosphatase Activity
Peptidyl-threonine Phosphorylation
Intracellular Signal Transduction
Neuron Development
Regulation Of Cellular Process
Pathways
Ion channel transport
Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions
15 interactors:
ACTC1
BCAM
CCDC43
CLK2
CUL3
KLHL12
SDCBP
TMA16
TNPO2
TXNDC12
UBE2C
UBE2D1
WNK1
WNK4
ZNF114
37 interactors:
ADRB2
AKT1
ARAF
ATP8
ATXN1
BAG3
CLTC
COPS5
CSDE1
E2F3
FHL3
FLNC
GLIS2
KLHL2
MAP2K1
MAP3K2
MAP3K3
NEDD4L
PFKP
PRKAR1A
PRKAR1B
PVR
RANBP9
RBX1
SLC9A1
SUMO1
SYT2
TNRC6A
TSC22D1
UBC
UPF2
WNK2
YWHAE
YWHAG
YWHAZ
ZNF106
ZYX
Entrez ID
11275
65125
HPRD ID
09311
05570
Ensembl ID
ENSG00000109466
ENSG00000060237
Uniprot IDs
O95198
A5D8Z4
F5GWT4
H6WZW3
Q9H4A3
PDB IDs
2XN4
Enriched GO Terms of Interacting Partners
?
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Pancreatic Juice Secretion
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Chromosome Segregation
Negative Regulation Of Transferase Activity
Regulation Of Mitotic Nuclear Division
COPII Vesicle Coating
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
COPII-coated Vesicle Budding
Positive Regulation Of Cellular Protein Catabolic Process
Protein Polyubiquitination
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Vesicle Targeting, To, From Or Within Golgi
Regulation Of Proteasomal Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Regulation Of Chromosome Organization
Spindle Assembly Checkpoint
Protein K48-linked Ubiquitination
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Catabolic Process
Protein Ubiquitination
Mitotic Spindle Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitotic Nuclear Division
Protein Monoubiquitination
Localization Within Membrane
Negative Regulation Of Chromosome Segregation
Vesicle Targeting
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Kinase Activity
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Spindle Checkpoint
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Cell Division
Proteasomal Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Positive Regulation Of Proteolysis
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Catalytic Activity
Cellular Protein Modification Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Signaling
Regulation Of Phosphorus Metabolic Process
Regulation Of Signal Transduction
Regulation Of Phosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Sodium Ion Transport
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cellular Response To Growth Factor Stimulus
Activation Of Protein Kinase Activity
Epidermal Growth Factor Receptor Signaling Pathway
Intracellular Transport
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Localization
Positive Regulation Of Sodium Ion Transport
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Response To Growth Factor
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Protein Kinase Activity
Response To Fibroblast Growth Factor
Cellular Response To Peptide
Signaling
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Kinase Activity
Establishment Of Localization In Cell
Signal Transduction
Cell Communication
Cellular Localization
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Transferase Activity
Regulation Of Protein Metabolic Process
Regulation Of Kinase Activity
Intracellular Signal Transduction
Positive Regulation Of Mitochondrion Organization
Cellular Response To Organic Substance
Regulation Of Cellular Localization
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Regulation Of Cellular Protein Metabolic Process
Response To Abiotic Stimulus
Positive Regulation Of Phosphorylation
Cellular Response To Mechanical Stimulus
Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud
?
alanine
associate
cation
ccc
cccs
chloride
compromise
cotransporters
disruption
hence
knock
lens
lenses
maintain
opacification
osr1
proline
rat
regionally
spak
ste20
subcellular
subcellularly
susceptibility
transcript
transcriptase
transparency
wet
Tagcloud (Difference)
?
alanine
associate
cation
ccc
cccs
chloride
compromise
cotransporters
disruption
hence
knock
lens
lenses
maintain
opacification
osr1
proline
rat
regionally
spak
ste20
subcellular
subcellularly
susceptibility
transcript
transcriptase
transparency
wet
Tagcloud (Intersection)
?