KLHL2 and TMA16

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		KLHL2	TMA16
Description		kelch like family member 2	translation machinery associated 16 homolog
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Preribosome Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Ribosome Biogenesis Ribosomal Large Subunit Biogenesis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Small cell lung carcinoma ( 28604730)
Interacting Genes		29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	9 interacting genes: AP2M1 APP CASTOR1 CEBPA IKBKG KLHL2 KRTAP10-7 NEDD4L TSPYL2
Entrez ID		11275	55319
HPRD ID		09311	07739
Ensembl ID		ENSG00000109466	ENSG00000198498
Uniprot IDs		B4DFZ5 E9PEX9 O95198	Q96EY4
PDB IDs		2XN4 4CHB	6LSS 6LU8 8FLA 8FLB 8FLC 8IDT 8IDY 8INE 8INF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis	Positive Regulation Of Proteolysis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Endocytosis Positive Regulation Of Receptor Internalization Identical Protein Binding Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Pit Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Lipoprotein Particle Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Endocytosis CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Receptor Internalization Linear Polyubiquitin Binding Negative Regulation Of Sodium Ion Import Across Plasma Membrane Molecular Sensor Activity Cellular Response To L-arginine Endocytosis Notch Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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