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KLHL12 and FLNA
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
KLHL12
FLNA
Description
kelch like family member 12
filamin A
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
COPII Vesicle Coat
COPII-coated ER To Golgi Transport Vesicle
Cytoplasmic Vesicle
Cul3-RING Ubiquitin Ligase Complex
Centriolar Satellite
Podosome
Extracellular Region
Nucleus
Nucleolus
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Actin Cytoskeleton
Membrane
Z Disc
Growth Cone
Cortical Cytoskeleton
Myb Complex
Cell Projection
Neuronal Cell Body
Dendritic Shaft
Perikaryon
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Anchoring Junction
Apical Dendrite
Postsynapse
Glutamatergic Synapse
Glycoprotein Ib-IX-V Complex
Molecular Function
Protein Binding
Identical Protein Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
G Protein-coupled Receptor Binding
RNA Binding
Actin Binding
Protein Binding
Potassium Channel Regulator Activity
Kinase Binding
Small GTPase Binding
Fc-gamma Receptor I Complex Binding
Protein Homodimerization Activity
Transmembrane Transporter Binding
Protein-containing Complex Binding
Cadherin Binding
SMAD Binding
Actin Filament Binding
GTPase Binding
DNA-binding Transcription Factor Binding
Protein Sequestering Activity
Biological Process
Protein Monoubiquitination
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Anatomical Structure Morphogenesis
Tissue Development
Neural Crest Formation
Neural Crest Cell Development
Wnt Signaling Pathway
Vesicle-mediated Transport
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
COPII Vesicle Coating
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Blood Coagulation, Intrinsic Pathway
Positive Regulation Of Platelet Activation
Negative Regulation Of Transcription By RNA Polymerase I
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Cell Projection Organization
Actin Cytoskeleton Organization
Regulation Of Cell Migration
Positive Regulation Of Actin Filament Bundle Assembly
Protein Localization To Cell Surface
Megakaryocyte Development
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Import Into Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of DNA-binding Transcription Factor Activity
Wound Healing, Spreading Of Cells
Establishment Of Protein Localization
Protein Stabilization
Release Of Sequestered Calcium Ion Into Cytosol
Actin Crosslink Formation
Cilium Assembly
Platelet Aggregation
Semaphorin-plexin Signaling Pathway
Protein Localization To Plasma Membrane
Tubulin Deacetylation
Mitotic Spindle Assembly
Establishment Of Sertoli Cell Barrier
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Potassium Ion Transmembrane Transport
Protein Localization To Bicellular Tight Junction
Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential
Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Integrin-mediated Signaling Pathway
Positive Regulation Of Neuron Migration
Pathways
Degradation of DVL
Platelet degranulation
GP1b-IX-V activation signalling
Cell-extracellular matrix interactions
RHO GTPases activate PAKs
OAS antiviral response
Drugs
Artenimol
Diseases
FG syndrome (FGS); Opitz-Kaveggia syndrome
Periventricular nodular heterotopia (PVNH)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
GWAS
Immature fraction of reticulocytes (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
58 interacting genes:
ARAF
ATXN1
BAG6
BCL6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CRTC3
CUL3
DGCR6
DRD4
DVL3
FAM90A1
FBXL17
FGD2
FLNA
GLYCTK
INMT
KEAP1
KLHL2
KLHL24
KLHL3
LNPK
LNX1
MAPRE1
MED25
MED28
MPP1
MRPL10
MTNR1A
MYO15B
NDC80
NTAQ1
PDCD6
PDGFRB
PEA15
PLEKHA4
PNKP
PRR13
RGL3
RIN1
RIT1
RNF4
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TCEANC
TTBK2
UBE2I
VEGFB
VTA1
ZBP1
ZBTB4
106 interacting genes:
ADAMTSL4
ANKRD13C-DT
APC
AR
ARHGAP24
ARRB1
ARRB2
ASB2
BRCA1
BRCA2
CALCR
CAMK2G
CASR
CAV1
CCNB1
CDC42
CDK1
CEACAM1
CEBPA
CFL1
CMIP
DCN
DDIT4L
DRD1
DRD2
DRD3
DUX4
ERBB3
F3
FABP1
FBLIM1
FILIP1
FLNB
FURIN
GP1BA
GRIK1
GRIK3
GRM4
GRM5
GRM7
GRM8
HMGB2
HNRNPD
HSPA6
ITGB1
ITGB3
ITGB5
ITGB6
ITGB7
KCNE4
KCNJ2
KLHL12
LGALS14
LMNA
MAP2K4
MAPK14
MCPH1
MTDH
MTNR1A
MTNR1B
MTOR
MYOT
MYOZ1
NLGN3
NPHP1
OPRM1
PAK1
PCBP2
PDE4B
PELO
PHOSPHO2
PLEKHF2
PRKCA
PSEN1
PSEN2
PTEN
RAC1
RALA
REL
RFLNA
RHOA
RNF10
SELE
SH2B3
SHBG
SIGLEC10
SIRPA
SMAD3
SMAD5
SPANXD
SRC
SUMO2
SVIL
SYNPO2
TCF4
TLR10
TNIP2
TP73
TRAF2
TRIM55
TRIO
TTN
USP19
VHL
XIAP
YWHAG
Entrez ID
59349
2316
HPRD ID
13925
02060
Ensembl ID
ENSG00000117153
ENSG00000196924
Uniprot IDs
Q53G59
Q9H7R2
P21333
Q60FE5
Q6NXF2
PDB IDs
2VPJ
6TTK
6V7O
8OIO
8RBH
2AAV
2BP3
2BRQ
2J3S
2JF1
2K3T
2K7P
2K7Q
2MTP
2W0P
2WFN
3CNK
3HOC
3HOP
3HOR
3ISW
3RGH
4M9P
4P3W
5XR1
6D8C
6EW1
7SC4
7SFT
9LWX
9LXG
Enriched GO Terms of Interacting Partners
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Cul3-RING Ubiquitin Ligase Complex
Protein Binding
Regulation Of Signal Transduction
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-like Ligase-substrate Adaptor Activity
Identical Protein Binding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Modification Process
POZ Domain Binding
Proteolysis Involved In Protein Catabolic Process
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Regulation Of Organelle Organization
Regulation Of Cell Communication
Regulation Of Signaling
Actin Cytoskeleton Organization
Positive Regulation Of Signal Transduction
Proteasomal Protein Catabolic Process
Positive Regulation Of Organelle Organization
Cytoskeleton Organization
Actin Filament-based Process
Paraspeckles
Protein K48-linked Ubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Cell Motility
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Motility
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cellular Component Assembly
Regulation Of Locomotion
Positive Regulation Of Locomotion
Regulation Of Cell Communication
Signal Transduction
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Intracellular Signaling Cassette
Negative Regulation Of Multicellular Organismal Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Migration
Regulation Of Biological Quality
Regulation Of Synaptic Transmission, Glutamatergic
Focal Adhesion
Regulation Of MAPK Cascade
Negative Regulation Of Signal Transduction
Positive Regulation Of Developmental Process
Cellular Response To Oxygen-containing Compound
Regulation Of Developmental Process
Cell Motility
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cellular Component Organization
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Modulation Of Chemical Synaptic Transmission
Regulation Of System Process
Regulation Of Membrane Potential
Glutamatergic Synapse
Enzyme Binding
Positive Regulation Of MAPK Cascade
Plasma Membrane
Response To Stress
Regulation Of Transport
Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway
Regulation Of Multicellular Organismal Development
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Differentiation
Cell Junction Organization
Positive Regulation Of Locomotion
Actin Filament-based Process
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Tagcloud (Intersection)
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