KLHL2 and PADI6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL2	PADI6
Description		kelch like family member 2	peptidyl arginine deiminase 6
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection	Nucleus Cytoplasm Cytoplasmic Vesicle Intermediate Filament Cytoskeleton Cortical Granule Cytoplasmic Lattice Ooplasm
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Tubulin Binding Identical Protein Binding Structural Constituent Of Cytoplasmic Lattice
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	In Utero Embryonic Development Cytoskeleton Organization Cytoplasm Organization Intracellular Protein Localization Embryonic Cleavage Regulation Of Translation By Machinery Localization Epigenetic Programming In The Zygotic Pronuclei Protein Storage
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Chromatin modifying enzymes
Drugs			Citrulline
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Basal cell carcinoma ( 18849993 24403052 25855136) Mean platelet volume ( 27863252)
Interacting Genes		29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	3 interacting genes: KLHL2 SUV39H1 ZNF526
Entrez ID		11275	353238
HPRD ID		09311	15095
Ensembl ID		ENSG00000109466	ENSG00000276747
Uniprot IDs		B4DFZ5 E9PEX9 O95198	Q6TGC4
PDB IDs		2XN4 4CHB	4DAT 4DAU 8QL0 9FMN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis	Nuclear Lamina Histone H3K9 Trimethyltransferase Activity Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose Histone H3K9 Methyltransferase Activity RDNA Heterochromatin Formation ENoSc Complex RDNA Heterochromatin Facultative Heterochromatin Formation Epigenetic Programming In The Zygotic Pronuclei Chromatin Silencing Complex S-adenosylmethionine-dependent Methyltransferase Activity Blastocyst Hatching Histone H3 Methyltransferase Activity
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