KLHL2 and TNPO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KLHL2	TNPO2
Description		kelch like family member 2	transportin 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection	Nucleus Cytoplasm
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Negative Regulation Of Muscle Cell Differentiation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)
Interacting Genes		29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	54 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CEBPA CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RBM45 REDIC1 RIPK4 RNF10 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 ZBTB32 ZC2HC1C
Entrez ID		11275	30000
HPRD ID		09311	04301
Ensembl ID		ENSG00000109466	ENSG00000105576
Uniprot IDs		B4DFZ5 E9PEX9 O95198	O14787 Q05D48
PDB IDs		2XN4 4CHB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis	Identical Protein Binding Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Binding Calcium/calmodulin-dependent Protein Kinase Activity Protein Homodimerization Activity
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