KLHL2 and TBKBP1

Number of citations of the paper that reports this interaction (PubMedID 19481056)
0

Data Source:
BioGRID (two hybrid)

		KLHL2	TBKBP1
Description		kelch like family member 2	TBK1 binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection	Cytoplasm Serine/threonine Protein Kinase Complex
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Immune System Process Innate Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Ankylosing spondylitis ( 21743469 23749187) Asthma ( 31619474) Asthma (childhood onset) ( 31036433) Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Human herpes virus 7 U14 antibody levels ( 33204752) Mean corpuscular hemoglobin ( 32888494) Multiple sclerosis ( 22190364) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	6 interacting genes: AGO2 APBA3 CTNND2 IRAK1 KLHL2 TUBB
Entrez ID		11275	9755
HPRD ID		09311	12239
Ensembl ID		ENSG00000109466	ENSG00000198933
Uniprot IDs		B4DFZ5 E9PEX9 O95198	A7MCY6
PDB IDs		2XN4 4CHB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis
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