RHOU and SIVA1

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	SIVA1
Description		ras homolog family member U	SIVA1 apoptosis inducing factor
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	Apoptotic Process Activation-induced Cell Death Of T Cells Negative Regulation Of Canonical NF-kappaB Signal Transduction Symbiont Entry Into Host Cell T Cell Receptor Signaling Pathway T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	33 interacting genes: ABL2 APP AQP1 BCL2 BCL2L1 BEX3 C2orf68 CATSPER1 CD27 CD4 CDKN2A CREB5 HOXA1 ING3 KRTAP26-1 MEFV NEDD4 NEDD4L NTAQ1 PCBP1 PCNA PM20D2 POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TFAP2D TNFRSF4 TXNIP UBE2D1 ZNF446
Entrez ID		58480	10572
HPRD ID		06965	16124
Ensembl ID		ENSG00000116574	ENSG00000184990
Uniprot IDs		Q7L0Q8	O15304
PDB IDs		2Q3H
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Response To Hydrogen Peroxide Channel Inhibitor Activity Identical Protein Binding Response To Reactive Oxygen Species Dendritic Cell Apoptotic Process Response To Radiation Response To Light Stimulus Response To Metal Ion BH3 Domain Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Response To Oxidative Stress Channel Activity Regulation Of Metabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Transcription By RNA Polymerase II Regulation Of Mononuclear Cell Proliferation Regulation Of B Cell Activation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Cell Activation Regulation Of Primary Metabolic Process Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Response To UV Protein Polyubiquitination Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Leukocyte Apoptotic Process Ubiquitin Ligase Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Cellular Response To Hydrogen Peroxide Regulation Of B Cell Proliferation T Cell Activation Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Sodium Ion Transport Cellular Response To Radiation Negative Regulation Of Cation Transmembrane Transport Regulation Of Mitochondrial Membrane Potential Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Monoatomic Ion Transmembrane Transport
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