SIVA1 and BEX3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SIVA1	BEX3
Description		SIVA1 apoptosis inducing factor	brain expressed X-linked 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Nucleus Cytoplasm Cytosol
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Signaling Receptor Binding Death Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Apoptotic Process Activation-induced Cell Death Of T Cells Negative Regulation Of Canonical NF-kappaB Signal Transduction Symbiont Entry Into Host Cell T Cell Receptor Signaling Pathway T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Ubiquitination
Pathways			NADE modulates death signalling
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		33 interacting genes: ABL2 APP AQP1 BCL2 BCL2L1 BEX3 C2orf68 CATSPER1 CD27 CD4 CDKN2A CREB5 HOXA1 ING3 KRTAP26-1 MEFV NEDD4 NEDD4L NTAQ1 PCBP1 PCNA PM20D2 POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TFAP2D TNFRSF4 TXNIP UBE2D1 ZNF446	43 interacting genes: AIMP2 BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO DSCR9 EMILIN1 ENKD1 FSD2 FTCD GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417
Entrez ID		10572	27018
HPRD ID		16124	02291
Ensembl ID		ENSG00000184990	ENSG00000166681
Uniprot IDs		O15304	Q00994
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Hydrogen Peroxide Channel Inhibitor Activity Identical Protein Binding Response To Reactive Oxygen Species Dendritic Cell Apoptotic Process Response To Radiation Response To Light Stimulus Response To Metal Ion BH3 Domain Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Response To Oxidative Stress Channel Activity Regulation Of Metabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Transcription By RNA Polymerase II Regulation Of Mononuclear Cell Proliferation Regulation Of B Cell Activation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Cell Activation Regulation Of Primary Metabolic Process Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Response To UV Protein Polyubiquitination Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Leukocyte Apoptotic Process Ubiquitin Ligase Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Cellular Response To Hydrogen Peroxide Regulation Of B Cell Proliferation T Cell Activation Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Sodium Ion Transport Cellular Response To Radiation Negative Regulation Of Cation Transmembrane Transport Regulation Of Mitochondrial Membrane Potential Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Monoatomic Ion Transmembrane Transport	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Programmed Cell Death CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction A2A Adenosine Receptor Binding DNA Replication-dependent Chromatin Disassembly Regulation Of MAPK Cascade Neurotrophin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Process Identical Protein Binding Cell Death Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Macrophage Migration S100 Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Cytoplasm Zinc Ion Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Histone H3K4me3 Reader Activity Regulation Of Macromolecule Metabolic Process
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