SIVA1 and NGFRAP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SIVA1	NGFRAP1
Gene Name		SIVA1, apoptosis-inducing factor	nerve growth factor receptor (TNFRSF16) associated protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Nucleus Cytoplasm Cytosol
	Molecular Function	Virus Receptor Activity CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Metal Ion Binding
	Biological Process	Activation-induced Cell Death Of T Cells Response To Virus Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organismal Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways			Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling NADE modulates death signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ABL2 APP BCL2L1 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L NGFRAP1 PCNA POLR2M PXMP2 RAD18 STMN1 TCAP TNFRSF4 UBE2D1	28 interactors: AIMP2 CACYBP CCDC116 CCDC85B CTNNBL1 DIABLO EMILIN1 FSD2 GOLGA8EP GOLGA8F MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 SIVA1 SMPD1 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSC1 USHBP1 VTA1 YWHAE
Entrez ID		10572	27018
HPRD ID		16124	02291
Ensembl ID		ENSG00000184990	ENSG00000166681
Uniprot IDs		O15304	Q00994
PDB IDs			1SA6
Enriched GO Terms of Interacting Partners?		Response To Stress Immune Response Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Response To Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Peptidase Activity Regulation Of Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Signal Transduction Regulation Of Endopeptidase Activity Immune System Process Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Response To Radiation Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Localization Signaling Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Neuron Remodeling Cell Communication Cell Surface Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Defense Response Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Modulation By Virus Of Host Process T Cell Aggregation T Cell Activation Protein Ubiquitination Lymphocyte Aggregation Leukocyte Aggregation Interaction With Host Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Hydrolase Activity Cell Death Leukocyte Cell-cell Adhesion	Regulation Of Cell Death Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process NIK/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Cellular Response To Stimulus Regulation Of MAPK Cascade Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway Response To Organic Substance MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	abcf2 adprtl1 amy2b arhgap4 atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4
Tagcloud (Difference) ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	abcf2 adprtl1 amy2b arhgap4 atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4
Tagcloud (Intersection) ?