SIVA1 and MEFV

Number of citations of the paper that reports this interaction (PMID 18330885)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SIVA1	MEFV
Gene Name		SIVA1, apoptosis-inducing factor	Mediterranean fever
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Ruffle Nucleus Cytosol Microtubule Microtubule Associated Complex Lamellipodium
	Molecular Function	Virus Receptor Activity CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Actin Binding Zinc Ion Binding
	Biological Process	Activation-induced Cell Death Of T Cells Response To Virus Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Inflammatory Response Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways			The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ABL2 APP BCL2L1 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L NGFRAP1 PCNA POLR2M PXMP2 RAD18 STMN1 TCAP TNFRSF4 UBE2D1	4 interactors: COG5 PSTPIP1 PYCARD SIVA1
Entrez ID		10572	4210
HPRD ID		16124	02012
Ensembl ID		ENSG00000184990	ENSG00000103313
Uniprot IDs		O15304	D2DTW2 O15553
PDB IDs			2WL1
Enriched GO Terms of Interacting Partners?		Response To Stress Immune Response Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Response To Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Peptidase Activity Regulation Of Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Signal Transduction Regulation Of Endopeptidase Activity Immune System Process Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Response To Radiation Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Localization Signaling Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Neuron Remodeling Cell Communication Cell Surface Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Defense Response Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Modulation By Virus Of Host Process T Cell Aggregation T Cell Activation Protein Ubiquitination Lymphocyte Aggregation Leukocyte Aggregation Interaction With Host Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Hydrolase Activity Cell Death Leukocyte Cell-cell Adhesion	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Mitochondrion Organization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Mitochondrion Organization Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Response To Virus Vesicle-mediated Transport Activation-induced Cell Death Of T Cells Macropinocytosis Positive Regulation Of Interleukin-6 Secretion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Chemokine Secretion Positive Regulation Of Organelle Organization Inflammatory Response Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Secretion Negative Regulation Of Interferon-beta Production Regulation Of Interleukin-8 Secretion Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Pinocytosis Positive Regulation Of Defense Response To Virus By Host Immune System Process T Cell Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Interleukin-10 Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of T Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Rac GTPase Activity Positive Regulation Of Activated T Cell Proliferation Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Cell Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Endocytosis Myeloid Dendritic Cell Activation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Regulation Of Defense Response To Virus By Host Response To Other Organism Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Tagcloud ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	aperture apnoea cephalometric collapsibility desaturation desaturations ent expiratory expiring fibroscopy fiv1 flows fvc hyoid hypopnoea inspiratory manoeuvre mef50 mifv mph muller osa palate pef pif shortest snorers spd spl
Tagcloud (Difference) ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	aperture apnoea cephalometric collapsibility desaturation desaturations ent expiratory expiring fibroscopy fiv1 flows fvc hyoid hypopnoea inspiratory manoeuvre mef50 mifv mph muller osa palate pef pif shortest snorers spd spl
Tagcloud (Intersection) ?