RHOU and ZFAND2B

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	ZFAND2B
Description		ras homolog family member U	zinc finger AN1-type containing 2B
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GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Proteasome Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Protein Binding Zinc Ion Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Protein Targeting To ER
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	6 interacting genes: DAZAP2 RHOU TARDBP UBC UBQLN1 UBQLN2
Entrez ID		58480	130617
HPRD ID		06965	11234
Ensembl ID		ENSG00000116574	ENSG00000158552
Uniprot IDs		Q7L0Q8	A0A087X0D9 Q8WV99
PDB IDs		2Q3H	1X4V
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Molecular Condensate Scaffold Activity Cytoplasmic Stress Granule Nuclear Inner Membrane Organization Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Modification-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Proteolysis Involved In Protein Catabolic Process Identical Protein Binding Organelle Assembly Interchromatin Granule Negative Regulation Of Clathrin-dependent Endocytosis Vacuole Organization Perichromatin Fibrils Regulation Of Macroautophagy Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Focal Adhesion Disassembly Endosome Membrane Macromolecule Catabolic Process Ubiquitin Protein Ligase Binding Host-mediated Suppression Of Viral Transcription Pre-mRNA Intronic Binding Autophagy Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Establishment Of Protein Localization Aggrephagy Proteolysis Protein Tag Activity Organelle Organization Mitogen-activated Protein Kinase Kinase Kinase Binding Host-mediated Suppression Of Viral Proces Negative Regulation Of Receptor Internalization 3'-UTR-mediated MRNA Destabilization Regulation Of Clathrin-dependent Endocytosis Regulation Of Protein Stability
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