SIVA1 and CD27

Number of citations of the paper that reports this interaction (PubMedID 9177220)
44

Data Source:
HPRD (two hybrid, in vitro)

		SIVA1	CD27
Description		SIVA1 apoptosis inducing factor	CD27 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Apoptotic Process Activation-induced Cell Death Of T Cells Negative Regulation Of Canonical NF-kappaB Signal Transduction Symbiont Entry Into Host Cell T Cell Receptor Signaling Pathway T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Apoptotic Process Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response T Cell Activation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			TNFs bind their physiological receptors
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) Thyroid stimulating hormone levels ( 32769997)	Crohn's disease ( 26192919)
Interacting Genes		33 interacting genes: ABL2 APP AQP1 BCL2 BCL2L1 BEX3 C2orf68 CATSPER1 CD27 CD4 CDKN2A CREB5 HOXA1 ING3 KRTAP26-1 MEFV NEDD4 NEDD4L NTAQ1 PCBP1 PCNA PM20D2 POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TFAP2D TNFRSF4 TXNIP UBE2D1 ZNF446	8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2
Entrez ID		10572	939
HPRD ID		16124	01723
Ensembl ID		ENSG00000184990	ENSG00000139193
Uniprot IDs		O15304	P26842
PDB IDs			5TL5 5TLJ 5TLK 7KX0 8DS5
Enriched GO Terms of Interacting Partners?		Response To Hydrogen Peroxide Channel Inhibitor Activity Identical Protein Binding Response To Reactive Oxygen Species Dendritic Cell Apoptotic Process Response To Radiation Response To Light Stimulus Response To Metal Ion BH3 Domain Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Response To Oxidative Stress Channel Activity Regulation Of Metabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Transcription By RNA Polymerase II Regulation Of Mononuclear Cell Proliferation Regulation Of B Cell Activation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Cell Activation Regulation Of Primary Metabolic Process Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Response To UV Protein Polyubiquitination Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Leukocyte Apoptotic Process Ubiquitin Ligase Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Cellular Response To Hydrogen Peroxide Regulation Of B Cell Proliferation T Cell Activation Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Sodium Ion Transport Cellular Response To Radiation Negative Regulation Of Cation Transmembrane Transport Regulation Of Mitochondrial Membrane Potential Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Monoatomic Ion Transmembrane Transport	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway CD27 Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Apoptotic Process Regulation Of RNA Metabolic Process Cell Death Programmed Cell Death Cytoplasmic Side Of Plasma Membrane Regulation Of Nucleobase-containing Compound Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Apoptotic Process Metal Ion Binding Regulation Of Programmed Cell Death Regulation Of Gene Expression Actin Filament Uncapping Positive Regulation Of Protein Phosphorylation TORC2 Complex Disassembly Positive Regulation Of Male Germ Cell Proliferation CD27 Receptor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Chromatin MRNA Stabilization Protein Autoubiquitination Titin Z Domain Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly
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