SIVA1 and CD27

Number of citations of the paper that reports this interaction (PMID 9177220)
34

Data Source:
HPRD (in vitro, two hybrid)

		SIVA1	CD27
Gene Name		SIVA1, apoptosis-inducing factor	CD27 molecule
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Extracellular Region Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Activation-induced Cell Death Of T Cells Response To Virus Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Cell Surface Receptor Signaling Pathway Release Of Cytoplasmic Sequestered NF-kappaB Immunoglobulin Mediated Immune Response Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ABL2 APP BCL2L1 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L NGFRAP1 PCNA POLR2M PXMP2 RAD18 STMN1 TCAP TNFRSF4 UBE2D1	7 interactors: CD5 CD70 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2
Entrez ID		10572	939
HPRD ID		16124	01723
Ensembl ID		ENSG00000184990	ENSG00000139193
Uniprot IDs		O15304	P26842
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stress Immune Response Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Response To Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Peptidase Activity Regulation Of Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Signal Transduction Regulation Of Endopeptidase Activity Immune System Process Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Response To Radiation Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Localization Signaling Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Neuron Remodeling Cell Communication Cell Surface Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Defense Response Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Modulation By Virus Of Host Process T Cell Aggregation T Cell Activation Protein Ubiquitination Lymphocyte Aggregation Leukocyte Aggregation Interaction With Host Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Hydrolase Activity Cell Death Leukocyte Cell-cell Adhesion	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Tumor Necrosis Factor-mediated Signaling Pathway Protein Autoubiquitination Apoptotic Signaling Pathway Immune System Process Negative Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Toll-like Receptor Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Signal Transduction Activation Of Innate Immune Response Cell Proliferation Signaling Cell Communication Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Immune System Process Activation-induced Cell Death Of T Cells Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Cellular Response To Stimulus Positive Regulation Of Protein Homodimerization Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Toll Signaling Pathway Cellular Response To Nitric Oxide Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Positive Regulation Of Signal Transduction
Tagcloud ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	alignment augments belongs cd30 cd40 cd70 coimmunoprecipitation contains disulfide dramatically eeeg homodimerization intact ligation mediator monomers p50 p52 p65 phenomena piqed pxqxt signal traf1 traf2 traf3 trafs uses works
Tagcloud (Difference) ?		accelerates advance closure coexpression cutaneous dermatology doi donut downregulate electrical epidermis epithelialization es explants hdm2 healing investigative jid journal keratinocyte minute obscure phospho publication shaped stratification upregulating wound wounds	alignment augments belongs cd30 cd40 cd70 coimmunoprecipitation contains disulfide dramatically eeeg homodimerization intact ligation mediator monomers p50 p52 p65 phenomena piqed pxqxt signal traf1 traf2 traf3 trafs uses works
Tagcloud (Intersection) ?