RHOU and KIAA1191

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		RHOU	KIAA1191
Description		ras homolog family member U	KIAA1191
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction	Cytoplasm Mitochondrion
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Protein Binding Oxidoreductase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	9 interacting genes: APP CACNA1A GSK3B NOL12 NOTCH1 POT1 PRNP RHOU SNCA
Entrez ID		58480	57179
HPRD ID		06965	13839
Ensembl ID		ENSG00000116574	ENSG00000122203
Uniprot IDs		Q7L0Q8	A0A087WT18 Q96A73
PDB IDs		2Q3H
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin	Cellular Response To Amyloid-beta Response To Amyloid-beta Cellular Response To Copper Ion Response To Copper Ion Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Positive Regulation Of Apoptotic Process Postsynapse Positive Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Apoptotic Process Cuprous Ion Binding Positive Regulation Of Establishment Of Protein Localization Regulation Of Calcium-mediated Signaling Negative Regulation Of Cellular Component Organization Negative Regulation Of Long-term Synaptic Potentiation Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Calcineurin-NFAT Signaling Cascade Intracellular Copper Ion Homeostasis Regulation Of Cellular Component Organization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Copper Ion Homeostasis Inclusion Body Regulation Of Protein Localization Regulation Of Neurotransmitter Uptake Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Localization Negative Regulation Of Calcium-mediated Signaling Regulation Of Presynapse Organization Negative Regulation Of Wnt Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Molecular Function Activator Activity Cellular Response To Metal Ion Negative Regulation Of Stem Cell Differentiation Regulation Of Establishment Of Protein Localization Amyloid Fibril Formation Regulation Of Neuron Differentiation Microglial Cell Activation Positive Regulation Of Cellular Component Organization Leukocyte Activation Involved In Inflammatory Response Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Exocytosis Regulation Of Calcineurin-mediated Signaling Regulation Of Calcium Ion Transport Import Into Cell
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